1644-87-7

Basic information

• Product Name: Benzene, 1-nitro-2-[(trifluoromethyl)thio]-
• CAS NO: 1644-87-7
• Molecular Formula: C7H4F3NO2S
• Molecular Weight: 223.175
• Mol File: 1644-87-7.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzene, 1-nitro-2-[(trifluoromethyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-nitro-2-[(trifluoromethyl)thio]-(1644-87-7)
• EPA Substance Registry System: Benzene, 1-nitro-2-[(trifluoromethyl)thio]-(1644-87-7)

Safety Data

• Hazardous Substances Data: 1644-87-7(Hazardous Substances Data)

Upstream product

• 1155-00-6 bis(2-nitrophenyl)disulfide 
• 126-33-0 sulfolane 
• 2923-16-2 potassium trifluoroacetate 
• 15898-45-0 sodium 2-nitrobenzenesulfinate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 456-56-4 phenyl trifluoromethylsulfide 
• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 811-68-7 silver(I) trifluoromethanethiolate 
• 88-74-4 2-nitro-aniline 
• 2769-30-4 2-nitrophenyl thiocyanate 
• 609-73-4 o-nitroiodobenzene 
• 22230-23-5 N-(2-trifluoromethylsulfanyl-phenyl)-phthalimide 
• 351-29-1 acetic acid-(3-trifluoromethylsulfanyl-anilide) 
• 3872-23-9 Copper(I) trifluoromethanethiolate 

Downstream Products

• 384-37-2 1-nitro-2-(trifluoromethylsulfonyl)benzene 
• 347-48-8 N-(2-((trifluoromethyl)thio)phenyl)acetamide 
• 88-75-5 2-hydroxynitrobenzene 
• 32858-96-1 2-Hydroxyphenyltrifluoromethylsulphone 
• 2358-41-0 1-fluoro-2-[(trifluoromethyl)sulfonyl]benzene 

Relevant articles and documents

THE INTRODUCTION OF SCF3 INTO AROMATIC SUBSTRATES USING CuSCF3 AND ALUMINA-SUPPORTED CuSCF3

Trifluoromethylthiocopper(I) has been readily prepared from the silver analogue, using a metathetical reaction with copper(I) bromide.Homogeneous CuSCF3 and the supported reagent CuSCF3-alumina have been compared in their reactivity towards aryl iodides, in order to form trifluoromethylaryl sulphides in good yields.

Transition-Metal-Free Synthesis of Aryl Trifluoromethyl Thioethers through Indirect Trifluoromethylthiolation of Sodium Arylsulfinate with TMSCF3

Herein, we report an indirect trifluoromethylthiolation of sodium arylsulfinates. This transition-metal-free reaction significantly provides an environmentally friendly and practical synthetic method for aryl trifluoromethyl thioethers using commercial Ruppert-Prakash reagent TMSCF3. This approach is also a potential alternative to the current industrial production method owing to facile substrates, excellent functional group compatibility, and operational simplicity.

Method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

The invention provides a method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. 2-nitroaniline is used as an initial raw material, is subjected to diazotization reaction, trifluoromethyl sulfonation reaction, fluoronation, chlorosulfonation reaction, and is reacted with ammonium hydroxide to finally produce the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. Comparedwith reported synthesis methods, the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has the advantages that the reaction yield of the synthesis route is high, used reaction agents are economic and easy to obtain, reaction conditions are mild and controllable, and in a reaction process, column chromatography and purification are not needed, so that the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has wide commercial application prospects.