384-97-4Relevant academic research and scientific papers
Generation of Carbocations under Photoredox Catalysis: Electrophilic Aromatic Substitution with 1-Fluoroalkylbenzyl Bromides
Gu, Yucheng,Hu, Jinbo,Kuang, Cuiwen,Ni, Chuanfa,Xie, Qiqiang,Zhou, Xin
supporting information, (2020/11/13)
A novel Friedel-Crafts-type alkylation of arenes to access valuable 1-fluoroalkyl-1,1-biaryl compounds is established under mild conditions. The key to success is the efficient generation of a destabilized benzylic carbocation intermediate via two consecutive single-electron transfer processes by virtue of visible-light photoredox catalysis. This unique activation pattern avoids using strong Lewis acids and high temperatures that are required for generation of destabilized carbocations in traditional Friedel-Crafts reactions. This protocol demonstrates the first example of photoredox-catalyzed heterolysis of electronically deactivated benzylic C-Br bonds for the formation of destabilized carbocation intermediates.
Bisphenol AF: Halogen bonding effect is a major driving force for the dual ERα-agonist and ERβ-antagonist activities
Liu, Xiaohui,Nose, Takeru,Shiki, Junichi,Shimohigashi, Miki,Shimohigashi, Yasuyuki,Suyama, Keitaro,Torikai, Kohei
, (2020/01/03)
17β-Estradiol (E2) is a natural steroid ligand for the structurally and physiologically independent estrogen receptors (ERs) ERα and ERβ. We recently observed that CF3-containing bisphenol AF (BPAF) works as an agonist for ERα but as an antagon
Regioselective substitution of phenols with trifluoroacetaldehyde ethyl hemiacetal
Gong,Kato,Kimoto
, p. 377 - 383 (2007/10/03)
2,2,2-Trifluoroethanols are of great interest because of their unique physical, chemical, and biological properties. Trifluoroacetaldehyde is a very efficient reagent for obtaining 2,2,2-trifluoroethanols. Because it is unavailable commercially, its hemia
ON THE REACTION OF INDOLE WITH SODIUM BOROHYDRIDE IN TRIFLUOROACETIC ACID
Gribble, Gordon W.,Nutaitis, Charles F.,Leese, Robert M.
, p. 379 - 386 (2007/10/02)
The reaction of indole (1) with sodium borohydride in trifluoroacetic acid gives, successively, indoline (3), N-(2,2,2-trifluoroethyl)indoline (4), and 1,1,1-trifluoro-2,2-bisethane (5), whose structure is established by chemical and spectral means.Similar reactions are observed with N-methylaniline (8) and anisole, but not with dibenzazepines 13 and 15, which give only N-trifluoroethylation.
