38401-70-6

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-BROMOPHENYL)THIOPHENE-2-CARBALDEHYDE is used as a building block for the synthesis of various organic compounds, particularly in the development of new pharmaceuticals. Its unique structure allows for the creation of diverse chemical entities with potential therapeutic applications.
Used in Materials Science:
In the field of materials science, 5-(4-BROMOPHENYL)THIOPHENE-2-CARBALDEHYDE is utilized as a key intermediate in the synthesis of advanced materials with specific properties. Its versatility in chemical reactions enables the development of materials with tailored characteristics for various applications, such as electronics, sensors, and coatings.
Used in Organic Synthesis:
5-(4-BROMOPHENYL)THIOPHENE-2-CARBALDEHYDE is employed as an important intermediate in organic synthesis due to its potential to exhibit a variety of chemical reactivities. Its presence in the synthesis process allows for the formation of complex organic molecules with specific functionalities, which can be further utilized in various chemical and industrial applications.

Upstream product

• 40133-22-0 2-(4-bromophenyl)thiophene 
• 68-12-2 N,N-dimethyl-formamide 
• 108-86-1 bromobenzene 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 5467-74-3 4-Bromophenylboronic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 4559-96-0 1-(4-bromophenyl)-4-chlorobutan-1-one 

Downstream Products

• 108967-84-6 2-(4-{(E)-2-[5-(4-Bromo-phenyl)-thiophen-2-yl]-vinyl}-phenyl)-5-phenyl-oxazole 
• 344417-31-8 2-Hydroxymethyl-5-(p-bromophenyl)thiophene 
• 108967-91-5 2-(4-{(E)-2-[5-(4-Bromo-phenyl)-thiophen-2-yl]-vinyl}-phenyl)-5-phenyl-[1,3,4]oxadiazole 
• 40133-13-9 5-(4-bromo-phenyl)-thiophene-2-carboxylic acid 
• 1195960-98-5 2-(4-((5-(4-bromophenyl)thiophen-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1236000-70-6 {[5-(4-bromophenyl)-2-thienyl]methyl}methyl({4[(trifluoromethyl)oxy]phenyl}methyl)amine 
• 1313397-37-3 5-((5-(4-bromophenyl)thiophen-2-yl)methylene)-2-thioxoimidazolidin-4-one 
• 85093-02-3 2-(p-bromophenyl)-5-methylthiophene 

Relevant academic research and scientific papers

Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane

As the continuous rise in the incidence of antibiotic resistance, it is urgent to develop novel chemical scaffolds with antibacterial activities to control the spread of resistance to conventional antibiotics. In this study, a series of phenylthiazole and

Synthesis and evaluation of thiophene-based guanylhydrazones (iminoguanidines) efficient against panel of voriconazole-resistant fungal isolates

A series of new thiophene-based guanylhydrazones (iminoguanidines) were synthesized in high yields using a straightforward two-step procedure. The antifungal activity of compounds was evaluated against a wide range of medicaly important fungal strains inc

Cyclic thiourea functionalized dyes with binary π-linkers: Influence of different π-conjugation segments on the performance of dye-sensitized solar cells

A series of cyclic thiourea functionalized dyes containing binary π-linkers were synthesized and applied in the dye-sensitized solar cells. The only difference of these dyes is that one segment of the binary π-linkers is thiophene, n-hexylthiophene, thienothiophene, 3,4-ethylenedioxythiophene, and benzene, respectively. Among them, the dyes incorporating electron-rich thienothiophene or 3,4-ethylenedioxythiophene exhibit the broader absorption bands and higher molar extinction coefficients in the visible region, which can not only enhance the light-harvesting ability but also improve the short-circuit current density; on the other hand, the dyes bearing bulky n-hexylthiophene or 3,4-ethylenedioxythiophene can effectively suppress the intermolecular π-π aggregation and electron recombination owing to larger steric hindrance, which is beneficial to increase the open-circuit voltage.

4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS

4-pyridone (4-pyridinone) derivatives of Formula (I) and pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical formulations thereof and their use in chemotherapy of certain parasitic infections such as malaria, are provided.

Development of dual functional SPECT/fluorescent probes for imaging cerebral β-amyloid plaques

The imaging of β-amyloid (Aβ) aggregates in the brain may lead to the early detection of Alzheimer's disease (AD) and monitoring of the progression and effectiveness of treatment. The purpose of this study was to develop dual modality SPECT and fluorescent probes based on boron dipyrromethane (BODIPY) as a core structure. We designed and synthesized an 125I-labeled derivative of BODIPY (BODIPY7). BODIPY7 had a K i value of 108 nM for Aβ(1-42) aggregates and exhibited peaks of absorption/emission at 606/613 nm. It detected Aβ plaques in sections of brain tissue from an animal model of AD and displayed low uptake in the brain and high uptake in the liver in normal mice. Although additional modifications of the BODIPY scaffold are necessary to improve brain uptake, these results should aid the development of dual functional SPECT/fluorescent probes for the imaging of Aβ plaques in the brain.

Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.