38411-82-4

Usage

Uses

Used in Neurochemistry Research:
2-(2-Aminoethyl)-5-Methoxybenzene-1,4-diol is used as a research compound for understanding the role and interactions of neurotransmitters in the central nervous system. Its structural similarity to dopamine allows researchers to investigate the mechanisms of neurochemical processes and neurotransmission.
Used in Neurodegenerative Disorder Studies:
In the field of neurodegenerative disorders, 2-(2-Aminoethyl)-5-Methoxybenzene-1,4-diol is used as a potential therapeutic agent. It has been explored for its possible applications in the treatment of conditions such as Parkinson's disease, where dopamine deficiency is a key factor.
Used in Oncology Research:
2-(2-Aminoethyl)-5-Methoxybenzene-1,4-diol is used as an anti-tumor agent in oncology research. Its potential in this field is currently under investigation, with the aim of understanding its effects on tumor growth and the possibility of developing new cancer treatments.
While the compound has shown promise in these areas, it is important to note that further research is necessary to fully comprehend its pharmacological and therapeutic properties, as well as to establish its safety and efficacy in clinical applications.

Upstream product

• 39816-36-9 [2-(3-Hydroxy-4-methoxy-phenyl)-ethyl]-carbamic acid benzyl ester 
• 3213-30-7 5-(2-amino-ethyl)-2-methoxy-phenol 
• 39816-35-8 2-(3-hydroxy-4-methoxyphenyl)-1-nitroethene 
• 95319-64-5 2,5-Diphenyloxy-4-methoxy-ω-nitro-styrol 
• 89635-08-5 2,5-dibenzyloxy-4-methoxybenzaldehyde 
• 621-59-0 isovanillin 
• 88440-96-4 1-(2,4,5-trimethoxyphenyl)-2-<(tert-butoxycarbonyl)amino>ethane 
• 88440-97-5 2-methoxy-5-<2-<(tert-butoxycarbonyl)amino>ethyl>-p-quinone 
• 15394-83-9 1-(2,4,5-trimethoxyphenyl)-2-aminoethane 
• 86255-45-0 1-(2,4,5-trimethoxyphenyl)-2-nitroethene 
• 39816-39-2 [2-(4-methoxy-3,6-dioxo-cyclohexa-1,4-dienyl)-ethyl]-carbamic acid benzyl ester 
• 88440-98-6 1-(2,5-dihydroxy-4-methoxyphenyl)-2-<(tert-butoxycarbonyl)amino>ethane 
• 39816-43-8 (2,5-dihydroxy-4-methoxy-phenethyl)-carbamic acid benzyl ester 

Downstream Products

• 1199-18-4 6-Hydroxydopamin 

Relevant academic research and scientific papers

Synthesis and physicochemical and neurotoxicity studies of 1-(4-substituted-2,5-dihydroxyphenyl)-2-aminoethane analogues of 6-hydroxydopamine

In an attempt to evaluate the possible relationship between the neurotoxicity of 6-hydroxydopamine and the redox properties and electrophilic reactivity of the 6-hydroxydopamine-p-hydroquinone/p-quinone system, we have synthesized a series of 6-hydroxydopamine analogues in which the C4-hydroxy group is replaced with various electron-donating and electron-withdrawing substituents. With the aid of cyclic voltammetry, the formal oxidation potentials (E°') for the p-hydroquinone/p-quinone redox couples and the rates of cyclization of the p-quinones to the corresponding p-iminoquinones were determined. As expected, electron-rich p-hydroquinones were easily oxidized to the p-quinones, which underwent cyclization slowly, whereas the oxidation of electron-poor p-hydroquinones required higher voltages and yielded p-quinones, which cyclized readily at pH 7.4. The neurotoxic potential of these compounds showed that in vivo destruction of noradrenergic terminals, as measured by inhibition of norepinephrine uptake by rat heart slices, occurred only with those analogues bearing electron-donating substituents. Potent neurotoxic properties were associated only with the 4-amino and 4-hydroxy derivatives, both of which form p-quinones, which do not cyclize readily at pH 7.4. These results support the thesis that the p-quinone derived from 6-hydroxydopamine may be an important species in the mediation of the neurodestruction caused by 6-hydrodopamine.