38417-02-6

Usage

Uses

Used in Pharmaceutical Industry:
Z-GLY-PRO-OSU is used as a synthetic intermediate for the synthesis of glycyl-L-prolyl-L-glutamic acid analogs, which are important in the development of drugs targeting various diseases and conditions. Its protective group allows for selective deprotection and coupling reactions, facilitating the creation of complex peptide structures with desired properties.
Used in Peptide Synthesis:
Z-GLY-PRO-OSU is used as a protected amino acid in the synthesis of peptides, ensuring that the molecule maintains its integrity during the reaction process. The benzyloxycarbonyl group protects the amino group, preventing unwanted side reactions and allowing for the controlled formation of peptide bonds.
Used in Research and Development:
In the field of research and development, Z-GLY-PRO-OSU is utilized for the synthesis and study of novel peptide-based compounds with potential therapeutic applications. Its use in the creation of analogs can lead to the discovery of new drugs and treatments for various medical conditions.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 1160-54-9 (2S)-1-(2-[[(benzyloxy)carbonyl]amino]acetyl)tetrahydro-1H-pyrrole-2-carboxylic acid 
• 147-85-3 L-proline 
• 66449-90-9 (2S)-N-(N-Benzyloxycarbonylglycyl)proline methyl ester 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 

Downstream Products

• 39622-01-0 Z-Gly-Pro-Gly-OBu^t 
• 841233-87-2 benzyl (4S)-N-benzyloxycarbonyl-glycyl-L-prolyl-4-amino-5-hydroxypentanoate 
• 108562-96-5 Boc-Cys(MBzl)-Gly-Pro-Gly-OBu^t 
• 840525-20-4 N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamine α-benzyl ester 
• 840525-21-5 N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-Nγ-methyl-glutamine α-benzyl ester 
• 840525-23-7 N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-Nγ,Nγ-dimethyl-glutamine α-benzyl ester 
• 840525-25-9 benzyl (2S)-N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-2-amino-5-hydroxypentanoate 
• 840525-19-1 α-benzyl N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamate 

Relevant academic research and scientific papers

The Study of Stability of Proline-Containing Derivatives of Dopamine and Serotonin in the Biological Media in Vitro Experiments

Abstract—: The peptides Boc-Gly-Pro-DP, Z-Gly-Pro-DP, LA-Gly-Pro-DP, Boc-Gly-Pro-Srt, Z-Gly-Pro-Srt have been synthesized for the first time. The study of their stability in the presence of leucine aminopeptidase, carboxypeptidase Y, carboxypeptidase B, and proline endopeptidase (PEP) has shown that the synthesized peptides are stable in the presence of aminopeptidases and carboxypeptidases. In the presence of PEP, dopamine (DP) and serotonin (Srt) have been cleaved from these substances. Thus, the originally synthesized proline derivatives of Srt and DP may be considered as the resources, from which Srt and DP can be gradually released. This creates the possibility of a prolonged action of these biologically active compounds on cells and, consequently, on the whole body.

Synthesis and pharmacological evaluation of side chain modified glutamic acid analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE)

The synthesis of eight GPE* analogues, wherein the γ-carboxylic moiety of the glutamic residue has been modified, is described by coupling readily accessible N-benzyloxycarbonyl-glycyl-l-proline with various analogues of glutamic acid. Pharmacological evaluation of the novel compounds was undertaken to further understand the role of the glutamate residue on the observed neuroprotective properties of the endogenous tripeptide GPE.

Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L- glutamic acid (GPE) modified at the α-carboxylic acid

The synthesis of nine GPE* analogues, wherein the α-carboxylic acid group of glutamic acid has been modified, is described by coupling readily accessible N-benzyloxycarbonyl-glycyl-l-proline 2 with various analogues of glutamic acid. Pharmacological evaluation of the novel compounds was undertaken to further understand the role of the glutamate residue on the observed neuroprotective properties of the endogenous tripeptide GPE.

A Chemical Model for the Activation of Pyruvate-Formate-Lyase

A chemical model is described for the activation of the carbon-centred radical-based enzyme, pyruvate-formate-lyase.The feasibility of a 5'-deoxyadensyl radical abstracting a hydrigen atom from C-2 of a peptideglycine residue has been demonstrated in an intramolecular process.