38426-10-7

Basic information

• Product Name: 2-chloro-N-[4-(dimethylamino)phenyl]acetamide hydrochloride
• Synonyms: 2-chloro-N-[4-(dimethylamino)phenyl]acetamide hydrochloride;2-Chloro-N-[4-(dimethylamino)phenyl]acetamide
• CAS NO: 38426-10-7
• Molecular Formula: C₁₀H₁₃ClN₂O
• Molecular Weight: 212.68
• Mol File: 38426-10-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-chloro-N-[4-(dimethylamino)phenyl]acetamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-[4-(dimethylamino)phenyl]acetamide hydrochloride(38426-10-7)
• EPA Substance Registry System: 2-chloro-N-[4-(dimethylamino)phenyl]acetamide hydrochloride(38426-10-7)

Safety Data

• Hazardous Substances Data: 38426-10-7(Hazardous Substances Data)

Upstream product

• 138-89-6 p-dimethylaminonitrosobenzene 
• 99-98-9 4-amino-N,N-dimethylaniline 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1189255-75-1 2-[({[4-(dimethylamino)phenyl]carbamoyl}methyl)sulfanyl]-7-hydroxy-5-oxo-4H,5H-thieno[3,2-b]pyridine-3-carboxamide 
• 1196537-49-1 N-{2-[4-(dimethylamino)anilino]-2-oxoethyl}-5-formyl-2,4-dimethyl-1H-pyrrole-3-formamide 
• 74481-67-7 2-amino-N-[4-(dimethylamino)phenyl]acetamide 
• 76809-84-2 C₁₇H₁₉N₃O₂ 
• 118989-55-2 N-(4-dimethylaminophenyl)-2-(4-(3-hydroxypropyl)-1-piperazinyl)acetamide 
• 118989-54-1 N-(4-dimethylaminophenyl)-2-(4-(2-hydroxyethyl)-1-piperazinyl)acetamide 
• 118989-79-0 N-(4-dimethylaminophenyl)-2-(4-methyl-1-piperazinyl)acetamide 
• 38426-12-9 N-(4-Dimethylamino-phenyl)-2-{2-[(4-dimethylamino-phenylcarbamoyl)-methylsulfanyl]-ethylsulfanyl}-acetamide 

Relevant articles and documents

Synthesis, biological evaluation, and structure-activity relationships of new tubulin polymerization inhibitors based on 5-amino-1,2,4-triazole scaffold

Based on our previous research, thirty new 5-amino-1H-1,2,4-triazoles possessing 3,4,5-trimethoxyphenyl moiety were synthesized, and evaluated for antiproliferative activities. Among them, compounds IIa, IIIh, and IIIm demonstrated significant antiproliferative activities against a panel of tumor cell lines, and the promising compound IIIm dose-dependently caused G2/M phase arrest in HeLa cells. Furthermore, analogue IIa exhibited the most potent tubulin polymerization inhibitory activity with an IC50 value of 9.4 μM, and molecular modeling studies revealed that IIa formed stable interactions in the colchicine-binding site of tubulin, suggesting that 5-amino-1H-1,2,4-triazole scaffold has potential for further investigation to develop novel tubulin polymerization inhibitors with anticancer activity.

Stereochemistry of Hexacoordinated Zn(II), Cu(II), Ni(II), and Co(II) Complexes with Iminodiacetamide Ligands

Metal complexes of iminodiacetamide (imda) ligands and metal ions Zn(II), Cu(II), Ni(II), and Co(II) were prepared using eight imda ligands (L1-L8) substituted with groups of different steric and electronic properties on the central amine N atom (H atom,

DIHYDROINDOLINONE DERIVATIVES

Disclosed are dihydroindolone compounds which can modulate the activity of protein tyrosine kinases, a method for preparing the same, and pharmaceutical compositions comprising the same. Also disclosed are use of such compounds and pharmaceutical compositions thereof in the treatment and/or prophylaxis of protein tyrosine kinase associated diseases in an organism, particularly in the treatment and/or prophylaxis of tumors and fibroblast proliferation associated diseases.