38443-06-0Relevant academic research and scientific papers
Regioselective reduction of 3-substituted 2,3-dihydrobenzothiadiazines with borohydrides
Battisti, Umberto M.,Cannazza, Giuseppe,Carrozzo, Marina M.,Braghiroli, Daniela,Parenti, Carlo,Rosato, Francesca,Troisi, Luigino
experimental part, p. 4433 - 4436 (2010/09/12)
A simple and efficient synthetic path for N-1 or N-2 alkyl-substituted 2-aminobenzenesulfonamides was developed based on regioselective reduction with NaBH3CN in different solvents.
A novel class of allosteric modulators of AMPA/Kainate receptors
Cannazza, Giuseppe,Jozwiak, Krzysztof,Parenti, Carlo,Braghiroli, Daniela,Carrozzo, Marina M.,Puia, Giulia,Losi, Gabriele,Baraldi, Mario,Lindner, Wolfgang,Wainer, Irving W.
supporting information; experimental part, p. 1254 - 1257 (2009/09/04)
The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.
