7720-45-8

Usage

Uses

Used in Pharmaceutical Industry:
2,5-DICHLORO-BENZENESULFONAMIDE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and medicines.
Used in Agrochemical Industry:
2,5-DICHLORO-BENZENESULFONAMIDE is used as a building block in the creation of agrochemicals, playing a role in the development of products designed to protect crops and enhance agricultural productivity.
Used as an Antimicrobial Agent:
2,5-DICHLORO-BENZENESULFONAMIDE is utilized as an antimicrobial agent in pharmaceutical products, where its antibacterial properties help combat infections and maintain hygiene.
Used in Dye Production:
It also serves as an intermediate in the production of dyes, contributing to the coloration and enhancement of various materials in different industries.
Safety Note:
Due to its potentially hazardous nature, it is crucial to handle 2,5-DICHLORO-BENZENESULFONAMIDE with caution and adhere to proper safety protocols during its use and manipulation.

InChI:InChI=1/C6H5Cl2NO2S/c7-4-1-2-5(8)6(3-4)12(9,10)11/h1-3H,(H2,9,10,11)

Upstream product

• 95-82-9 2,5 dichloroaniline 
• 106-46-7 para-dichlorobenzene 
• 5402-73-3 2,5-dichlorobenzenesulphonyl chloride 

Downstream Products

• 99586-06-8 (2,5-dichloro-benzenesulfonyl)-carbamic acid ethyl ester 
• 1429321-36-7 C₁₀H₁₂Cl₂N₂O₂S₂ 
• 64902-97-2 1-(2,5-dichlorophenylsulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea 
• 7019-16-1 2,5-dichlorobenzenesulfonyl isocyanate 
• 1254305-48-0 C₁₅H₇Cl₃F₃N₃O₃S 
• 1416326-48-1 C₂₆H₁₇Cl₄FN₂O₄S 
• 1355221-94-1 1-((2,4-dioxothiazolidin-5-yl) methyl)-3-(2',5'-dichlorobenzenesulfonyl) urea 
• 474876-42-1 5-chloro-2-(isopropylamino)benzenesulfonamide 
• 38443-06-0 5-chloro-2-(ethylamino)benzenesulfonamide 
• 1143477-78-4 5-chloro-2-(propylamino)benzenesulfonamide 
• 103754-29-6 N-(2,5-dichloro-benzenesulfonyl)-N'-propyl-urea 
• 99453-18-6 N-(5-amino-1H-1,2,4-triazol-3-yl)-2,5-dichlorobenzenesulfonamide 
• 99453-16-4 N'-cyano-N-<(2,5dichlorophenyl)sulfonyl>-S-methylisothiourea 
• 53486-54-7 5-chloro-2-(methylamino)benzenesulfonamide 

Relevant academic research and scientific papers

1,4,2-Benzo/pyridodithiazine 1,1-dioxides structurally related to the ATP-sensitive potassium channel openers 1,2,4-Benzo/pyridothiadiazine 1,1-dioxides exert a myorelaxant activity linked to a distinct mechanism of action

The synthesis of diversely substituted 3-alkyl/aralkyl/arylamino-1,4,2- benzodithiazine 1,1-dioxides and 3-alkylaminopyrido[4,3-e]-1,4,2-dithiazine 1,1-dioxides is described. Their biological activities on pancreatic β-cells and on smooth muscle cells were compared to those of the reference ATP-sensitive potassium channel (KATP channel) openers diazoxide and 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide. The aim was to assess the impact on biological activities of the replacement of the 1,2,4-thiadiazine ring by an isosteric 1,4,2-dithiazine ring. Most of the dithiazine analogues were found to be inactive on the pancreatic tissue, although some compounds bearing a 1-phenylethylamino side chain at the 3-position exerted a marked myorelaxant activity. Such an effect did not appear to be related to the opening of KATP channels but rather reflected a mechanism of action similar to that of calcium channel blockers. Tightly related 3-(1-phenylethyl)sulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxides were also found to exert a pronounced myorelaxant activity, resulting from both a K ATP channel activation and a calcium channel blocker mechanism. The present work highlights the critical importance of an intracyclic NH group at the 4-position, as well as an exocyclic NH group linked to the 3-position of the benzo- and pyridothiadiazine dioxides, for activity on KATP channels.

N-(phenylsulfonyl)picolinamide derivatives, process for producing the same, and herbicide

A herbicide containing as the active ingredient an N-(henylsulfonyl)picolinamide derivative represented by general formula (I) wherein X reprcsents a halogeno, a C1-4 alkyl, a C1-4 haloalkyl, a C1-4 alkoxy, a C1-4 haloalkoxy, a (C1-4 alkoxy)carbonyl, a [di(C1-4 alkyl)amino]sulfonyl, an [N—(C1-4 alkyl)-N—(C1-4 alkoxy)amino]sulfonyl, a (C1-4 alkylamino)sulfonyl, a C1-4 alkylthio, a C1-4 alkylsulfinyl, a C1-4 alkylsulfonyl, or nitro; n is an integer of 0 to 5; Y represets a halogeno, a C1-4 alkyl, a C1-4 haloalkyl, a C1-4 alkoxy, C1-4 haloalkoxy, a C1-4 alkylthio, a C1-4 haloalkylthio, amino, a C1-4 alkylamino, a di(C1-4 alkyl)amino, a (C1-4 alkoxy) C1-4 alkyl, a (C1-4 alkylthio) C1-4 alkyl, or nitro; and m is an integer of 0 to 4. This active ingredient is synthesized by condensing a substituted picolinic acid with a substituted benzenesulfonamide under dehydration, or by reacting the phenyl ester of a substituted picolinic acid with a substituted benzenesulfonamide in the presence of a basic compound.