38453-75-7Relevant academic research and scientific papers
First TDAE Reactivity Using Benzonitrile Derivatives as Substrates and Its Application to the Synthesis of 3-Substituted Isochroman-1-ones
Khoumeri, Omar,Terme, Thierry,Vanelle, Patrice
, p. 2617 - 2623 (2018/05/03)
The first TDAE-initiated reaction between benzonitrile derivatives as substrates and substituted benzaldehydes to form substituted hydroxyethylbenzonitrile derivatives is reported. The 2-hydroxyethyl benzonitrile derivatives thus formed were good candidat
A Photocatalytic Meerwein Approach to the Synthesis of Isochromanones and Isochromenones
Crespi, Stefano,J?ger, Stefanie,K?nig, Burkhard,Fagnoni, Maurizio
, p. 2147 - 2153 (2017/04/24)
A visible-light RuII photoredox Meerwein synthesis of isochromanones and isochromenones is described starting from diazonium salts of differently substituted anthranilic acids and various alkenes. This approach has allowed the reliable and effi
Expeditious synthesis of 3,4-dihydroisocoumarins and phthalides using the Heck-Matsuda reaction
Da Penha, Eduardo T.,Forni, José Augusto,Biajoli, André F.P.,Correia, Carlos Roque D.
scheme or table, p. 6342 - 6345 (2011/12/21)
Several 3,4-dihydroisocoumarins and phthalides were synthesized by an effective Heck-Matsuda reaction involving an ortho carboxybenzenediazonium salt with a series of styrenes bearing electron donating and electron withdrawing groups, methylvinyl ketone,
Titanocene(III) chloride mediated radical-induced synthesis of 3,4-dihydroisocoumarins: synthesis of (±)-hydrangenol, (±)-phyllodulcin, (±)-macrophyllol and (±)-thunberginol G
Mandal, Samir Kumar,Roy, Subhas Chandra
experimental part, p. 11050 - 11057 (2009/04/11)
A radical-promoted synthesis of 3,4-dihydroisocoumarins has been achieved in moderate to good yields using titanocene(III) chloride (Cp2TiCl) as the radical initiator. The total synthesis of four naturally occurring dihydrocoumarins hydrangenol, phyllodulcin, macrophyllol and thunberginol G has been accomplished using the radical technology. Cp2TiCl was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and Zn-dust in THF under argon.
Radical-mediated synthesis of 3,4-dihydroisocoumarins: total synthesis of hydrangenol
Mandal, Samir Kumar,Roy, Subhas Chandra
, p. 4131 - 4134 (2008/02/03)
A radically promoted synthesis of 3,4-dihydroisocoumarins has been achieved in moderate to good yields using titanocene(III) chloride (Cp2TiCl) as the radical initiator. The total synthesis of (±)-hydrangenol has been completed using this radical technology. Cp2TiCl was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and Zn-dust in THF under argon.
A case of pictet-spengler revisited: Application to the synthesis of dihydroisocoumarins
Choukchou-Braham,Mostefa-Kara,Cheikh,Didi,Villemin
, p. 169 - 178 (2007/10/03)
The reaction of Pictet-Spengler was revisited, and its modified conditions were applied to develop a general methodology toward the synthesis of dihydroisocoumarins containing a no-electron rich aromatic ring.
Synthesis of some new 3-(chlorophenyl)isocoumarins and their conversion to 3,4-dihydro derivatives
Rama, Nasim H.,Iqbal,Rauf,Rao, Muhammad I.,Zamani,Raza, Abdul R.
, p. 338 - 341 (2007/10/03)
Condensation of homophthalic acid 4 with chlorobenzoyl chlorides 5a-c yields 3-(chlorophenyl)isocoumarins 6a-c which on alkaline hydrolysis give the keto-acids 7a-c. (dl)-3-(Chlorophenyl)-3,4-dihydroisocoumarins 10a-c have been obtained by the reduction of 7a-c to racemic hydroxyacids 9a-c followed by cyclodehydration using acetic anhydride.
