38470-22-3

Usage

InChI:InChI=1/C9H10FNO2/c10-7-1-3-8(4-2-7)11-6-5-9(12)13/h1-4,11H,5-6H2,(H,12,13)

Upstream product

• 380190-11-4 3-((4-fluorophenyl)amino)propanenitrile 
• 79-10-7 acrylic acid 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 959995-91-6 3-(4-chloro-N-(4-fluorophenyl)phenylsulfonamido)propanoic acid 
• 38470-26-7 6-fluoro-2,3-dihydroquinolin-4(1H)-one 

Relevant academic research and scientific papers

Preparation method of 4-chloro-6-fluoroquinoline

The invention discloses a preparation method of 4-chloro-6-fluoroquinoline. The preparation method comprises the steps: with fluoroaniline as a starting material, firstly, carrying out Michael addition reaction with acrylic acid to obtain an intermediate 3-(4-fluoroanilino)propionic acid; followed by, carrying out a condensation cyclization reaction to obtain an intermediate 6-fluoro-2,3-dihydroquinoline-4(1H)-one; and finally, carrying out halogenation and dehydrogenation reaction to obtain 4-chloro-6-fluoroquinoline. The preparation method has the advantages of wide raw material sources and relatively low cost, thereby having relatively low production cost; at the same time, the preparation method has the advantages of relatively short synthesis route and relatively high yield, especially has mild reaction conditions, has no need of special high temperature equipment, and is suitable for industrialized mass production.

Fused, Tricyclic Sulfonamide Inhibitors of Gamma Secretase

The invention provides compounds of formula I: or pharmaceutically salts thereof where R1, R2, and the A, B, and C-rings are as defined herein. Compounds of formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's disease. The invention also encompasses pharmaceutical compositions comprising compounds or salts of formula I, methods of preparing the desired compounds, and methods of treating cognitive disorders, such as Alzheimer's disease, using the compounds or salts of formula I.

Cyclization products of N-fluorophenyl-β-alanines and their properties

Interaction of 2-and 4-fluorophenylamines with acrylic and itaconic acids leads to the synthesis of the corresponding N-substituted β-alanines, the cyclization of which leads to derivatives of dihydropyrimidinone, 4-carboxy-2-pyrrolidinone, and tetrahydro