3848-44-0Relevant academic research and scientific papers
Cardioselective Anti-Ischemic ATP-Sensitive Potassium Channel Openers. 3. Structure-Activity Studies on Benzopyranyl Cyanoguanidines: Modification of the Cyanoguanidine Portion
Atwal, Karnail S.,Grover, Gary J.,Ahmed, Syed Z.,Sleph, Paul G.,Dzwonczyk, Steven,et al.
, p. 3236 - 3245 (1995)
Structure-activity relationships for the cyanoguanidine portion of the lead cardiac selective ATP-sensitive potassium channel (KATP) opener (3) are described.The cyanoguanidine moiety appears to be optimal since increasing or decreasing the dis
NOVEL 4-(AZACYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS
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Page/Page column 36, (2010/06/20)
The present invention relates to novel 4- (azacycloalkyl) benzene-1, 3-diol compounds corresponding to general formula (I) below: Formula (I) to the compositions containing same, to the process for the preparation thereof and to the use thereof in pharmaceutical or cosmetic compositions for use in the treatment or prevention of pigmentary disorders.
TRP-M8 RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
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Page/Page column 61, (2009/07/17)
Tetrahydroisoquinoline compounds of formula (I), and compositions containing them, for the treatment of acute, inflammatory and neurophatic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neurophatic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintened pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
Phosphinic ester substituted benzopyran derivatives
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, (2008/06/13)
STR1 and pharmaceutically acceptable salts thereof wherein Y is a single bond, --CH 2 --, --C(O)--, --S-- or --N(R 11)--; and R 1 to R 6 are as defined herein. These compounds have potassium channel activating activity and are useful, therefore for example, as cardiovascular agents.
Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
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, (2008/06/13)
A new method for the treatment of ischemic conditions and arrhythmia is disclosed. The method uses compounds of the formula STR1 wherein A can be --CH2 --, --O--, --NR9 --, --S--, --SO--, --SO2 --; X can be oxygen or sulfu
