Cardioselective Anti-Ischemic ATP-Sensitive Potassium Channel Openers. 3. Structure-Activity Studies on Benzopyranyl Cyanoguanidines: Modification of the Cyanoguanidine Portion

DOI: 10.1021/jm00017a007

Source and publish data:

Journal of Medicinal Chemistry p. 3236 - 3245 (1995)

Update date:2022-08-05

Topics:

Authors:

Atwal, Karnail S.

Grover, Gary J.

Ahmed, Syed Z.

Sleph, Paul G.

Dzwonczyk, Steven

et al. et al.

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Article abstract of DOI:10.1021/jm00017a007

Structure-activity relationships for the cyanoguanidine portion of the lead cardiac selective ATP-sensitive potassium channel (K_ATP) opener (3) are described.The cyanoguanidine moiety appears to be optimal since increasing or decreasing the dis

Full text of DOI:10.1021/jm00017a007

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