38483-84-0Relevant academic research and scientific papers
Highly versatile synthesis of polyamines by Ns-strategy on a novel trityl chloride resin
Kan, Toshiyuki,Kobayashi, Hideki,Fukuyama, Tohru
, p. 1338 - 1340 (2007/10/03)
A solid-phase synthesis of polyamines on 4-alkoxytrityl chloride resin 5 is described. By alkylation of nitrobenzenesulfonamide 8 with alkyl halide 7 prepared from the resin 5, spermine bound resin 10 was efficiently synthesized. Condensation of 10 and tyrosine derivative followed by deprotection and cleavage from the resin afforded highly pure philanthotoxin-343 (4).
Esters of l-dopa: structure-hydrolysis relationships and ability to induce circling behaviour in an experimental model of hemiparkinsonism
Brunner-Guenat,Carrupt,Lisa,Testa,Rose,Thomas,Jenner,Ventura
, p. 861 - 869 (2007/10/03)
A number of carboxylate esters of L-dopa, some of which are novel, were examined for their physicochemical and biological properties. A few esters of tyrosine and phenylalanine were included for comparison. The compounds displayed great differences in their lipophilicity and stability towards chemical and enzymatic (human plasma) hydrolysis. Within subseries, relationships exist between structural properties and rate constants of chemical or enzymatic hydrolysis. In an experimental model of hemiparkinsonism (circling behaviour in rats), some of the L-dopa esters (the isopropyl, sec-butyl and 2-(tetrahydropyranyl)methyl esters) showed an activity distinctly greater than that of L-dopa, although the difference was not statistically significant.
Synthesis of novel and photolabile philanthotoxin analogs: Glutamate receptor antagonists
Choi,Goodnow,Kalivretenos,Chiles,Fushiya,Nakanishi
, p. 4793 - 4822 (2007/10/02)
The synthetic methods for 27 novel and photolabile philanthotoxin analogs are described. Most analogs were synthesized by two general methods with modifications of these methods where necessary.
