474070-52-5Relevant academic research and scientific papers
Highly versatile synthesis of polyamines by Ns-strategy on a novel trityl chloride resin
Kan, Toshiyuki,Kobayashi, Hideki,Fukuyama, Tohru
, p. 1338 - 1340 (2007/10/03)
A solid-phase synthesis of polyamines on 4-alkoxytrityl chloride resin 5 is described. By alkylation of nitrobenzenesulfonamide 8 with alkyl halide 7 prepared from the resin 5, spermine bound resin 10 was efficiently synthesized. Condensation of 10 and tyrosine derivative followed by deprotection and cleavage from the resin afforded highly pure philanthotoxin-343 (4).
