38489-70-2

Basic information

• Product Name: (E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid
• Synonyms: (E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid
• CAS NO: 38489-70-2
• Molecular Formula: C10H8O4
• Molecular Weight: 192.16812
• Mol File: 38489-70-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid(38489-70-2)
• EPA Substance Registry System: (E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid(38489-70-2)

Safety Data

• Hazardous Substances Data: 38489-70-2(Hazardous Substances Data)

Usage

General Description

"(E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid" is a chemical compound with the molecular formula C10H8O4. It is a derivative of acrylic acid and contains a benzo[d][1,3]dioxole ring structure. (E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid is commonly used in the pharmaceutical and agrochemical industries and has potential applications in the synthesis of various organic compounds. It may also have biological activity and could be of interest for further research in medicinal chemistry and drug development. Additionally, (E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid may have potential industrial uses in the production of polymers or other materials.

Upstream product

• 7797-83-3 2H-benzo[d]1,3-dioxolane-4-carbaldehyde 
• 141-82-2 malonic acid 
• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 303-38-8 2,3-Dihydroxybenzoic acid 
• 69151-39-9 NU 1034 
• 5768-39-8 benzo[1,3]dioxole-4-carboxylic acid 
• 66411-55-0 2,3-(Methylenedioxy)benzoyl chloride 
• 161886-19-7 benzo[1,3]dioxole-4-carbonitrile 
• 110-89-4 piperidine 
• 110-86-1 pyridine 

Downstream Products

• 20974-68-9 3-<2,3-(methylenedioxy)phenyl>propanoic acid 

Relevant articles and documents

PYRIDINONE ANTAGONISTS OF ALPHA-4 INTEGRINS

The present invention provides compounds that are alpha4 integrin antagonists having a structure according to the following formula (I) or a tautomer, mixture of tautomers, salt or solvate thereof, wherein Cy, ring A, m, n, p, R1, R2

Nonneurotoxic Tetralin and Indian Analogues of 3,4-(Methylenedioxy)amphetamine (MDA)

Four cyclic analgues of the psychoactive phenethylamine derivative 3,4-(methylenedioxy)amphetamine were studied.These congeners, 5,6- and 4,5-(methylenedioxy)-2-aminoindan (3a and 4a, respectively), and 6,7- and 5,6-(methylenedioxy)-2-aminotetralin (3b and 4b, respectively) were tested for stimulus generalization in the two-lever drug-discrimination paradigm.Two groups of rats were trained to discriminate either LSD tartrate (0.08 mg/kg) from saline, or (+/-)-MDMA*HCl (1.75 mg/kg) from saline.In addition, a 2-aminoindan (5a) and 2-aminotetralin (5b) congener of the hallucinogenic amphetamine 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) were also evaluated.None of the methylenedioxy compounds substituted in LSD-trained rats, while both 3a and 3b fully substituted in MDMA-trained rats.Compounds 4a and 4b did not substitute in MDMA-trained rats.Compounds 5a and 5b did not substitute in MDMA-trained rats, although 5a substituted in LSD-trained rats, but with relatively low potency compared to its open-chain counterpart.In view of the now well-established serotonin neurotoxicity of 3,4-(methylenedioxy)amphetamine and its N-methyl homologue 1, 3a and 3b were evaluated and compared to 1 for similar toxic effects following a single acute dose of 40 mg/kg sc.Sacrifice at 1 week showed that neither 3a nor 3b depressed rat cortical or hippocampal 5-HT or 5-HIAA levels nor were the number of binding sites (Bmax) depressed for paroxetine.By contrast, and in agreement with other reports, 1 significantly depressed all three indices of neurotoxicity.These results indicate that 3a and 3b have acute behavioral pharmacology similar to 1 but that they lack similar serotonin neurotoxicity.