69151-39-9

Usage

Uses

Used in Agricultural Industry:
Carbofuran is used as a broad-spectrum insecticide for controlling a variety of pests that can damage crops. Its application is aimed at protecting agricultural yields by reducing the impact of insect infestations.
However, due to its high toxicity to non-target organisms, including beneficial insects, birds, mammals, and aquatic life, the use of carbofuran has raised significant environmental and health concerns. As a result, its application has been restricted or banned in many countries to mitigate the potential adverse effects on ecosystems and human health. Alternative, less toxic pesticides or integrated pest management strategies are often recommended to replace carbofuran in agricultural practices.

InChI:InChI=1/C8H7NO3/c9-8(10)5-2-1-3-6-7(5)12-4-11-6/h1-3H,4H2,(H2,9,10)

Upstream product

• 66411-55-0 2,3-(Methylenedioxy)benzoyl chloride 
• 5768-39-8 benzo[1,3]dioxole-4-carboxylic acid 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 2411-83-8 methyl-2,3-dihydroxybenzoate 
• 33842-16-9 benzo[1,3]dioxole-4-carboxylic acid methyl ester 
• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 303-38-8 2,3-Dihydroxybenzoic acid 
• 24677-78-9 2,3-dihydroxybenzaldehyde 
• 7797-83-3 2H-benzo[d]1,3-dioxolane-4-carbaldehyde 

Downstream Products

• 161886-19-7 benzo[1,3]dioxole-4-carbonitrile 
• 1668-84-4 benzo[d][1,3]dioxol-4-amine 
• 7797-83-3 2H-benzo[d]1,3-dioxolane-4-carbaldehyde 
• 38489-70-2 2,3-(methylenedioxy)cinnamic acid 
• 482-32-6 kokusagine 

Relevant academic research and scientific papers

Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3,4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors

Poly(ADP-ribose) polymerase 1 (PARP1), a widely explored anticancer drug target, plays an important role in single-strand DNA break repair processes. High-throughput virtual screening (HTVS) of a Maybridge small molecule library using the PARP1-benzimidazole-4-carboxamide co-crystal structure and pharmacophore model led to the identification of eleven compounds. These compounds were evaluated using recombinant PARP1 enzyme assay that resulted in the acquisition of three PARP1 inhibitors: 3 (IC50 = 12 μM), 4 (IC50 = 5.8 μM), and 10 (IC50 = 0.88 μM). Compound 4 (2,3-dihydro-1,4-benzodioxine-5-carboxamide) was selected as a lead and was subjected to further chemical modifications, involving analogue synthesis and scaffold hopping. These efforts led to the identification of (Z)-2-(4-hydroxybenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide (49, IC50 = 0.082 μM) as the most potent inhibitor of PARP1 from the series.