38519-13-0

Usage

Compound type

Aromatic diamine compound.

Common uses

Production of dyes and pigments, synthesis of pharmaceuticals, precursor in the production of polymers and plastics.

Derivative

Benzene.

Functional group

Diamine.

Solubility

Soluble in organic solvents.

Metal ion interaction

Ability to form stable complexes with metal ions.

Hazardous nature

Potentially hazardous chemical, toxic and carcinogenic properties.

Handling precautions

Should be handled with caution.

Upstream product

• 339255-52-6 N'-(2-chloro-4-nitro-phenyl)-N,N-diethyl-ethane-1,2-diamine 
• 100-00-5 4-chlorobenzonitrile 
• 1965-54-4 N-(2-hydroxyethyl)-4-nitroaniline 
• 100418-51-7 2-((4-nitrophenyl)amino)ethyl methanesulfonate 
• 5464-09-5 N,N-diethyl-N'-(4-nitrophenyl)-1,2-diaminoethane 
• 100-01-6 4-nitro-aniline 
• 100-35-6 2-(diethylamino)ethyl chloride 
• 56223-75-7 N,N-diethyl-N'-(4-nitro-phenyl)-ethylenediamine; hydrochloride 
• 122-80-5 N-acetyl-p-phenylenediamine 

Downstream Products

• 38519-61-8 N-benzothiazol-2-yl-N'-(2-diethylamino-ethyl)-benzene-1,4-diamine 

Relevant academic research and scientific papers

Structure-activity relationship of quinoline derivatives as potent and selective α2c-adrenoceptor antagonists

Starting from two acridine compounds identified in a high-throughput screening campaign (1 and 2, Table 1), a series of 4-aminoquinolines was synthesized and tested for their properties on the human α2- adrenoceptor subtypes (α2A, α2B, and α2C). A number of compounds with good antagonist potencies against the α2C-adrenoceptor and excellent subtype selectivities over the other two subtypes were discovered. For example, (R)-{4-[4-(3,4-dimethylpiperazin-1-yl)phenylamino]quinolin-3-yl}methanol 6j had an antagonist potency of 8.5 nM against, and a subtype selectivity of more than 200-fold for, the α2c-adrenoceptor. Investigation of the structure-activity relationship identified a number of structural features, the most critical of which was an absolute need for a substituent in the 3-position of the quinoline ring. The 3-position on the piperazine ring was also found to play an appreciable role, as substitutions in that position exerted a significant and stereospecific beneficial effect on the α2C- adrenoceptor affinity and potency. Replacing the piperazine ring proved difficult, with 1,4-diazepanes representing the only viable alternative.

NOVEL AMIDE COMPOUNDS WITH MCH ANTAGONISTIC EFFECT AND MEDICAMENTS COMPRISING SAID COMPOUNDS

The invention relates to amide compounds of general formula (I), in which the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. The invention further relates to medicaments comprising at least one of said amides. Said medicaments are suitable for the treatment of metabolic disorders and/or eating disorders, in particular, obesity, bulimia, anorexia, hyperphagia, and diabetes as a result of the MCH receptor antagonism.