38520-87-5

Upstream product

• 80473-69-4 lithium dibutylcyanocuprate 
• 622403-42-3 1-phenyl-3-(2-ethoxycarbonylphenyl) carbodiimide 
• 179039-70-4 ethyl 2-(triphenylphosphoranylidene-amino)benzoate 
• 90408-05-2 o-azidobenzoic acid ethyl ester 
• 38511-65-8 2-butyl-3-phenyl-2,3-dihydroquinazolin-4(1H)-one 
• 4424-17-3 2-aminobenzanilide 

Relevant academic research and scientific papers

Copper-Catalyzed Tandem Reaction of 2-Aminobenzamides with Tertiary Amines for the Synthesis of Quinazolinone Derivatives

We developed a copper-catalyzed tandem reaction of 2-aminobenzamides with tertiary amines for the formation of quinazolinone derivatives. The strategy includes two steps (cyclization and coupling) performed in one pot. A number of substrates reacted well under standard conditions to give the corresponding quinazolinone derivatives in moderate to good yields.

Functionalized carbodiimide mediated synthesis of 2,3-disubstituted quinazolin-4(3 H)-ones via the tandem strategy of C-nucleophilic addition and intramolecular NH-substitution cyclization

A facile synthesis of quinazolin-4(3H)-ones possessing carbon substituents at positions 2 and 3 has been developed. Key to the synthesis is a tandem strategy involving introduction of a 2-substituent and construction of the quinazolinone framework via C-nucleophilic addition to the carbodiimide cumulenic carbon followed by intramolecular nucleophilic substitution by the newly formed NH moiety at the proximal ester group.