179039-70-4Relevant academic research and scientific papers
Synthesis and bioactivity evaluation of novel arylimines containing a 3-aminoethyl-2-[(p-trifluoromethoxy)anilino]-4(3H)-quinazolinone moiety
Wang, Xiang,Li, Pei,Li, Zhining,Yin, Juan,He, Ming,Xue, Wei,Chen, Zhiwei,Song, Baoan
, p. 9575 - 9582 (2013)
Twenty-seven novel (E)-3-[2-arylideneaminoethyl]-2-[4-(trifluoromethoxy) anilino]-4(3H)-quinazolinone derivatives were synthesized by reacting various aromatic aldehydes with intermediate 6. The target compounds were characterized by 1H NMR, s
Design, synthesis, and evaluation of new 4(3H)-quinazolinone derivatives containing a pyrazole carboxamide moiety
Wang, Xiang,Wang, Xiaoyu,Zhou, Banghua,Long, Jiefeng,Li, Pei
, p. 2109 - 2116 (2021/07/10)
A total of 15 new 4(3H)-quinazolinone derivatives containing a pyrazole carboxamide moiety were designed and synthesized in this study. The structures of the target compounds were elucidated using 1H NMR, 13C NMR, MS, and elemental a
1, 3, 5-substituent-4-pyrazole amide derivative and preparation method thereof
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Paragraph 0045; 0064; 0074-0075, (2020/02/14)
The invention discloses a 1, 3, 5-substituent-4-pyrazole amide derivative and a preparation method of the 1, 3, 5-substituent-4-pyrazole amide derivative. The 1, 3, 5-substituent-4-pyrazole amide derivative has a general formula disclosed by the invention
Nitrogen heterocyclic compound having 2-phenylamino-3-aminoalkylquinazoline-4-(3H)-one structure
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, (2017/09/04)
The invention relates to a nitrogen heterocyclic compound having a 2-arylamine-3-aminoalkylquinazoline-4-(3H)-one structure. The nitrogen heterocyclic compound is represented as the general formula (I), wherein R1, R2, R3 and R4 are hydrogen atoms, haloge
Novel 4(3H)-Quinazolinone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Bioactivity Evaluation
Xiang, Wang,Cheng-hao, Tang,Guo-lan, Wei,Jie-feng, Long
, p. 3220 - 3226 (2017/10/06)
The aim of the present study is to design and synthesize a series of novel 4(3H)-quinazolinone derivatives containing an isoxazole moiety and evaluate their antifungal activity against Gibberella zeae (G. zeae), Fusarium oxysporum (F. oxysporum), Cytospor
Functionalized carbodiimide mediated synthesis of 2,3-disubstituted quinazolin-4(3 H)-ones via the tandem strategy of C-nucleophilic addition and intramolecular NH-substitution cyclization
Nakano, Hayato,Kutsumura, Noriki,Saito, Takao
supporting information, p. 3179 - 3184 (2012/11/14)
A facile synthesis of quinazolin-4(3H)-ones possessing carbon substituents at positions 2 and 3 has been developed. Key to the synthesis is a tandem strategy involving introduction of a 2-substituent and construction of the quinazolinone framework via C-nucleophilic addition to the carbodiimide cumulenic carbon followed by intramolecular nucleophilic substitution by the newly formed NH moiety at the proximal ester group.
A facile synthesis of 2-amino-3H-quinazolin-4-ones with tandem aza- Wittig reaction
Ding, Ming-Wu,Zeng, Gui-Ping,Wu, Tian-Jie
, p. 1599 - 1604 (2007/10/03)
2-Amino-3H-quinazolin-4-ones 8 were prepared from tandem aza-Wittig reaction of iminophosphorane 5 with aromatic isocyanate and nucleaphilic reagent HY in mild condition.
