90408-05-2

Upstream product

• 64-17-5 ethanol 
• 31162-13-7 2-azidobenzoic acid 
• 32045-49-1 ethyl-o-aminobenzoate hydrochloride 
• 380430-53-5 2-(ethoxycarbonyl)phenylboronic acid 
• 118-92-3 anthranilic acid 
• 34897-85-3 o-azidobenzoyl chloride 
• 87-25-2 2-ethoxycarbonylaniline 
• 118-48-9 isatoic anhydride 

Downstream Products

• 179039-70-4 ethyl 2-(triphenylphosphoranylidene-amino)benzoate 
• 2385-23-1 2-Methyl-3-phenyl-4(3H)-quinazolinone 
• 22316-59-2 2-methyl-3-p-tolyl-4(3H)-quinazolinone 
• 1788-93-8 3-(4-chlorophenyl)-2-methyl-3H-quinazolin-4-one 
• 30507-16-5 3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one 
• 4260-34-8 3-benzyl-2-methyl-3H-quinazolin-4-one 
• 5260-41-3 2-ethyl-3-phenyl-3H-quinazolin-4-one 
• 50498-61-8 2-ethyl-3-(4-methylphenyl)quinazolin-4(3H)-one 
• 92873-43-3 3-(4-chlorophenyl)-2-ethylquinazolin-4(3H)-one 
• 297762-56-2 3-benzyl-2-ethyl-3,4-dihydroquinazolin-4-one 
• 22686-82-4 2,3-diphenyl-3H-quinazolin-4-one 
• 37856-14-7 2-phenyl-3-(4-tolyl)quinazolin-4(3H)-one 
• 19857-35-3 2-phenyl-3-(4-chlorophenyl)-quinazoline-4(3H)-one 
• 26060-02-6 2-phenyl-3-n-propylquinazoline-4(3H)-one 

Relevant academic research and scientific papers

Nickel Boride Catalyzed Reductions of Nitro Compounds and Azides: Nanocellulose-Supported Catalysts in Tandem Reactions

Nickel boride catalyst prepared in situ from NiCl2 and sodium borohydride allowed, in the presence of an aqueous solution of TEMPO-oxidized nanocellulose (0.01 wt%), the reduction of a wide range of nitroarenes and aliphatic nitro compounds. Here we describe how the modified nanocellulose has a stabilizing effect on the catalyst that enables low loading of the nickel salt pre-catalyst. Ni-B prepared in situ from a methanolic solution was also used to develop a greener and facile reduction of organic azides, offering a substantially lowered catalyst loading with respect to reported methods in the literature. Both aromatic and aliphatic azides were reduced, and the protocol is compatible with a one-pot Boc-protection of the obtained amine yielding the corresponding carbamates. Finally, bacterial crystalline nanocellulose was chosen as a support for the Ni-B catalyst to allow an easy recovery step of the catalyst and its recyclability for new reduction cycles.

Design, synthesis, and evaluation of new 4(3H)-quinazolinone derivatives containing a pyrazole carboxamide moiety

A total of 15 new 4(3H)-quinazolinone derivatives containing a pyrazole carboxamide moiety were designed and synthesized in this study. The structures of the target compounds were elucidated using 1H NMR, 13C NMR, MS, and elemental a

1, 3, 5-substituent-4-pyrazole amide derivative and preparation method thereof

The invention discloses a 1, 3, 5-substituent-4-pyrazole amide derivative and a preparation method of the 1, 3, 5-substituent-4-pyrazole amide derivative. The 1, 3, 5-substituent-4-pyrazole amide derivative has a general formula disclosed by the invention

Nitrogen heterocyclic compound having 2-phenylamino-3-aminoalkylquinazoline-4-(3H)-one structure

The invention relates to a nitrogen heterocyclic compound having a 2-arylamine-3-aminoalkylquinazoline-4-(3H)-one structure. The nitrogen heterocyclic compound is represented as the general formula (I), wherein R1, R2, R3 and R4 are hydrogen atoms, haloge

Novel 4(3H)-Quinazolinone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Bioactivity Evaluation

The aim of the present study is to design and synthesize a series of novel 4(3H)-quinazolinone derivatives containing an isoxazole moiety and evaluate their antifungal activity against Gibberella zeae (G. zeae), Fusarium oxysporum (F. oxysporum), Cytospor

Aromatic azido-selective reduction via the staudinger reaction using tri-n-butylphosphonium tetrafluoroborate with triethylamine

An efficient method for the reduction of aromatic azides to anilines via the Staudinger reaction using tri-n-butylphosphonium tetrafluoroborate with triethylamine in aqueous tetrahydrofuran solution is reported. The method enables the aromatic azido-selective reduction of 3-azido-5-(azidomethyl)benzene derivatives to efficiently afford anilines bearing an azidomethyl group.

Photochemical synthesis of 6-substituted 12-oxo-6,12-dihydroazepino[2,1-b]quinazolines

[Figure not available: see fulltext.] A method for the synthesis of 6-substituted 12-oxo-6,12-dihydroazepino[2,1-b]quinazolines via a photoinitiated reaction of orthosubstituted aryl azides with sodium 2-aminobenzoate is proposed. Stepwise annulation of t

Synthesis and biological evaluation of triazole based uracil derivatives as novel DPP-4 inhibitors

A series of triazole based uracil derivatives were designed and synthesized as novel DPP-4 inhibitors. Compound A01 was identified as a lead compound for SAR studies focused on the structural modification at the S2′ subsite of DPP-4. The novel analogues A02-A25 were obtained by modifying the substituents at the phenyl group, and B01-B09, by introducing the carbonyl group. On screening in DPP-4, compounds B03, B04 and B08 showed a significant improvement in DPP-4 inhibitory activities compared to compound A01 and showed comparable activities to the marketed DPP-4 inhibitor, alogliptin. Docking studies revealed new favorable binding modes of designed compounds in the S2′ subsite and proved that structural modifications in the S2′ subsite were an effective option to increase the inhibition of DPP-4. In vitro DPP-8 and DPP-9 tests indicated that all compounds showed excellent selectivity against DPP-8 and DPP-9. Further in vivo evaluation showed that compound B04 could significantly improve oral glucose tolerance in ICR mice and dose-dependently reduced glucose levels in type 2 diabetic C57BL/6 mice. These data suggest that compound B04 could be a promising DPP-4 inhibitor for future treatment of T2DM.

Synthesis and bioactivity evaluation of novel arylimines containing a 3-aminoethyl-2-[(p-trifluoromethoxy)anilino]-4(3H)-quinazolinone moiety

Twenty-seven novel (E)-3-[2-arylideneaminoethyl]-2-[4-(trifluoromethoxy) anilino]-4(3H)-quinazolinone derivatives were synthesized by reacting various aromatic aldehydes with intermediate 6. The target compounds were characterized by 1H NMR, s

Synthesis and cytotoxicity of some d-mannose click conjugates with aminobenzoic acid derivatives

Two sets of new conjugates obtained from d-mannose derivatives and o-, m-, and p-substituted benzoic acid esters interconnected through a triazole ring were synthesized by Cu(I) catalyzed azide-alkyne cycloaddition. All synthesized compounds were tested for their in vitro cytotoxic activity against seven cancer cell lines with/without multidrug resistance phenotype as well as non-tumor MRC-5 and BJ fibroblasts. Butyl ester of 4-aminobenzoic acid 6c showed the highest activity among all tested compounds, however, it was active only against K562 myeloid leukemia cells. N-Glycosyltriazole conjugates, both acetylated and nonacetylated at mannose moiety, were almost completely inactive. In contrast, some of the acetylated O-glycosyl conjugates showed cytotoxic activity which was cell line dependent and strongly affected by position of benzoic acid substitution as well as a length of its ester alkyl chain; the most potent compound was acetylated mannoside conjugated with octyl ester of m-substituted benzoic acid. However, deacetylation resulting in hydrophilicity increase of the glycosides almost completely abolished their cytotoxic potency.