38527-75-2

Usage

Physical state

white solid

Solubility

insoluble in water, soluble in organic solvents

Main use

precursor in organic synthesis

Applications

production of pharmaceuticals, agrochemicals, specialty chemicals

Properties

versatile compound, valuable building block in organic synthesis

Safety concerns

irritant to skin, eyes, respiratory system, requires proper safety measures

Upstream product

• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 13922-03-7 2,2'-iminobis(2-methylpropionitrile) 
• 19355-69-2 2-amino-2-cyanopropane 

Downstream Products

• 1352788-63-6 Bn₂-4-(3,3,5,5-tetramethyl-2,6-dioxopiperazin-1-yl)-L-Phg-OBn 
• 1363913-43-2 C₁₆H₂₁N₃O₄ 
• 1352788-64-7 Fmoc-4-(3,3,5,5-tetramethyl-2,6-dioxopiperazin-1-yl)-L-Phg-OH 
• 1352788-57-8 Fmoc-4-(3,3,5,5-tetramethyl-2,6-dioxo-4-oxylpiperazin-1-yl)-L-Phg-OH 

Relevant academic research and scientific papers

Novel N-chloroheterocyclic antimicrobials

Antimicrobial compounds with broad-spectrum activity and minimal potential for antibiotic resistance are urgently needed. Toward this end, we prepared and investigated a novel series of N-chloroheterocycles. Of the compounds examined, the N-chloroamine series were found superior over N-chloroamide series in regards to exhibiting high antimicrobial activity, low cytotoxicity, and long-term aqueous stability.

TOPP: A novel nitroxide-labeled amino acid for EPR distance measurements

A new tool: The amino acid 4-(3,3,5,5-tetramethyl-2,6-dioxo-4- oxylpiperazin-1-yl)-L-phenylglycine (TOPP), which has a rigid nitroxide spin label, can be used for EPR-based distance measurements in peptides. The key feature of the design is the defined orientation of the nitroxide in space with respect to the peptide backbone. EPR measurements provide evidence for the low conformational flexibility of the TOPP label. Copyright

Compositions stabilized by dioxopiperazinyl derivatives

Polyoxymethylene, blends of polycarbonate with acrylonitrile-butadiene-styrene terpolymer, and coatings based on a functional acrylate resin and a crosslinking agent, which are stabilized by addition of a compound of the formula I wherein s is from the range 1 to 8; R1, R2, R3and R4, independently of each other, are C1-C4alkyl, or R1and R2or R3and R4, together with the carbon atom to which they are bound, form a cyclopentyl or cyclohexyl ring; R5is hydrogen; C1-C18alkyl; oxyl; OH; CH2CN; C1-C18alkoxy; C5-C12cycloalkoxy; C3-C8alkenyl; C3-C8alkynyl; C7-C12phenylalkyl; C7-C15phenylalkyl, which is substituted on the phenyl ring by 1, 2 or 3 radicals selected from C1-C4alkyl and C1-C4alkoxy; C7-C15phenylalkoxy; C7-C15phenylalkoxy, which is substituted on the phenyl ring by 1, 2 or 3 radicals selected from C1-C4alkyl and C1-C4alkoxy; or R5is C1-C8alkanoyl; C3-C5alkenoyl; C1-C18alkanoyloxy; glycidyl; or a group —CH2CH(OH)-G, in which G is hydrogen, methyl or phenyl; and A is as described in claim 1, show a good resistance against harmful effects of light, oxygen and heat.

The Reactions of Guanidine and Urea with Cyanohydrines

Action of guanidine or urea on cyclohexanone-, cyclopentanone-, cycloheptanone- and acetonecyanohydrine 3a-3d generates very different products: 3a reacts with guanidine in DMF to yield 1,3-diazaspirodecane-2,4-diimine (5a).Heating the components without solvent affords 7,14-diazadispiropentadecan-15-one (7), the guanidine not participating in the reaction; similarly 3b is transformed by guanidine to a pentacyclic dispirocompound (possible formulae 19 and 20), whereas 3d reacts to give 3,3,5,5-tetramethylpiperazine-2,6-dion (21).In 3-pentanone guanidine- cyanide condensates itself to give 2,4-diamino-triazine (22).Action of urea on 3a-3d yields the 4-imino-1,3-diazaspiroalkan-2-ones 6a-6c and the 4-imino-5,5-dimethylimidazolidin-2-one 6d resp.If the reaction of urea and 3d is carried out in DMF, however, 5,5-dimethyl-4-ureido-3-imidazolin-2-one (28) (or the tautomeric carbamoyliminoimidazolidinone 27) is produced.The structures of the compounds prepared are proved by NMR-, IR- and mass spectra. - Keywords: 1.3-Diazaspiroalkan-2-ones. 4-imino; 1.3-Diazaspirodecan-2.4-diimine; Guanidine-cyanide. reactions with ketones; Guanidine. reactions with cyanohydrines; 2-Imidazolines, 4-imino-5.5-disubstituted; Urea. reactions with cyanohydrines

Substituted piperazine diones and polymeric compositions stabilized thereby

Substituted piperazine diones are stabilizers for synthetic polymeric materials normally subject to deterioration caused by ultraviolet light. The compounds are prepared by the alkylation reaction between a substituted piperazine dione and an organic halide. Polymeric compositions containing these stabilizers may also contain a hindered phenolic compound. A typical embodiment is 15,15'-dodecamethylenebis(7,15-diazadispiro[5,1,5,3]hexadecane-14,16-dione).