38565-11-6Relevant academic research and scientific papers
Sulfamic acid catalyzed direct condensation of aldehydes, amines, and TMSCN to α-aminonitriles at ambient temperature
Li, Zhenjiang,Sun, Yingjie,Ren, Xinghua,Wei, Ping,Shi, Yuhu,Ouyang, Pingkai
, p. 803 - 805 (2007/12/25)
A simple and efficient method has been developed for the synthesis of α-aminonitriles by a one-pot three-component condensation of aldehydes, amines, and trimethylsilyl cyanide in the presence of a catalytic amount of sulfamic acid at room temperature. Georg Thieme Verlag Stuttgart.
Organocatalytic activation of TMSCN by basic ammonium salts for efficient cyanation of aldehydes and imines
Raj, I. Victor Paul,Suryavanshi, Gurunath,Sudalai
, p. 7211 - 7214 (2008/03/11)
Basic ammonium salts act as highly effective catalysts for the cyanosilylation of aldehydes and in Strecker-type aminonitrile synthesis using TMSCN as cyanide source at 25 °C under extremely mild conditions, affording very good to excellent yields of silylated cyanohydrins and α-aminonitriles.
Cu(OTf)2 or Et3N-catalyzed three-component condensation of aldehydes, amines and cyanides: a high yielding synthesis of α-aminonitriles
Paraskar, Abhimanyu S.,Sudalai, Arumugam
, p. 5759 - 5762 (2007/10/03)
Copper(II) triflate or Et3N have been found to catalyze, under ambient conditions, the addition of a cyanide anion, such as trimethylsilyl cyanide or acetone cyanohydrin, onto in situ generated imines, furnishing α-aminonitriles in excellent yi
