385784-89-4

Upstream product

• 385784-88-3 5-methoxy-4-[(1-methylpiperidin-4-yl)methoxy]-2-nitrobenzonitrile 
• 20691-89-8 1-methyl-4-piperidinemethanol 
• 243128-37-2 4-fluoro-3-methoxybenzonitrile 
• 870959-63-0 3-methoxy-4-[(1-methylpiperidin-4-yl)methoxy]benzonitrile 

Downstream Products

• 870959-64-1 N-(4-chloro-2,5-dimethoxyphenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine 

Relevant academic research and scientific papers

QUINONE SUBSTITUTED QUINAZOLINE AND QUINOLINE KINASE INHIBITORS

The present invention provides for compounds with the general formula: A compound of formula (1) having the structure (1) wherein Z is a radical selected from the group (a), (b), or (c) as well as methods and compositions containing these compounds useful

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS

The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed