386-73-2

Basic information

• Product Name: 4-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE
• Synonyms: 4-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE;4-(trifluoroMethyl)indoline-2,3-dione;4-(Trifluoromethyl)-2,3-indoledione;4-(Trifluoromethyl)isatin
• CAS NO: 386-73-2
• Molecular Formula: C₉H₄F₃NO₂
• Molecular Weight: 215.13
• Mol File: 386-73-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 224-257℃ (decomposition)
• Appearance: /
• Density: 1.525 g/cm³
• Storage Temp.: 2-8°C
• PKA: 8.91±0.20(Predicted)
• CAS DataBase Reference: 4-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE(386-73-2)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE(386-73-2)

Safety Data

• Hazardous Substances Data: 386-73-2(Hazardous Substances Data)

Usage

General Description

4-(Trifluoromethyl)-1H-indole-2,3-dione is a chemical compound with a molecular formula C9H5F3NO2. It is a yellow solid with a melting point of 126-128 °C and is insoluble in water. 4-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE is often used as an intermediate in the synthesis of pharmaceuticals and organic compounds. Its trifluoromethyl group makes it valuable in medicinal chemistry for introducing fluorine atoms into molecules, which can improve their pharmacokinetic properties. The indole-2,3-dione moiety is also significant in biological and pharmaceutical applications due to its potential as a pharmacophore. 4-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE has attracted attention for its potential use in drug design and discovery due to its unique structure and properties.

Upstream product

• 404-83-1 N-(3-trifluoromethylphenyl)-2-oxyiminoacetamide 
• 259667-42-0 3-methylthio-4-trifluoromethyloxindole 
• 7447-39-4 copper(II) chloride 

Downstream Products

• 385764-32-9 (+/-)-3-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-hydroxy-4-(trifluoromethyl)-2H-indol-2-one 
• 131141-22-5 C₁₇H₁₀ClF₃N₂O₂S 
• 130020-22-3 C₁₈H₁₀F₆N₂O₂S 
• 130020-21-2 C₁₇H₁₀ClF₃N₂O₂S 
• 133116-90-2 di-t-butyl 5-trifluoromethyl-5,8-dideazaisofolate 
• 133116-89-9 di-t-butyl 5-trifluoromethyl-5,8-dideazafolate 
• 133116-92-4 5-trifluoromethyl-5,8-dideazaisofolic acid 
• 133116-91-3 5-trifluoromethyl-5,8-dideazafolic acid 
• 125908-21-6 C₂₀H₁₃F₃N₄O₂S 
• 125930-82-7 4-trifluoromethyl-3'-phenylspiro<3H-indole-3,2'-thiazolidine>-2(1H),4'-dione 
• 75564-99-7 1-Morpholin-4-ylmethyl-4-trifluoromethyl-3-[(E)-3-trifluoromethyl-phenylimino]-1,3-dihydro-indol-2-one 
• 97311-52-9 C₁₇H₁₁F₄N₃O 
• 97311-42-7 3-[2-(4-Fluoro-phenyl)-2-oxo-eth-(Z)-ylidene]-4-trifluoromethyl-1,3-dihydro-indol-2-one 
• 124929-33-5 1,3-dihydro-4-trifluoromethyl-3-(2-oxocyclohexylidene)indole-2-one 

Relevant articles and documents

Novel synthesis of 4-or 6-substituted indirubin derivatives

A simple and convenient route for synthesis of a series of 4-or 6-substituted indirubin derivatives by oxidation and subsequent condensation of indoxyl and isatin is described. Acidic reaction conditions are crucial to the condensation of 4-substituted derivatives, whereas for the condensation of 6-substituted derivatives, both acidic and basic conditions work well. Copyright Taylor & Francis Group, LLC.

Pyridazinedione compounds useful in treating neurological disorders

The present invention relates to pyridazino[4,5-b]quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical compositions containing pyridazino[4,5-b]quinolines as active ingredient, and methods for the treatment of neurological disorders.

Antimicrobial activity of fluorinated 1,2-benzisothiazol-3(2H)-ones and 2,2'-dithiobis(benzamides)

Fluoro and trifluoromethyl derivatives of 1,2-benzisothiazol-3(2H)-ones and the 2,2'-dithiobis(benzamides) have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were found highly active against fungi and Gram-positive microorganisms and a few derivatives displayed some activity against Gram-negative strains. Structure-activity relationships are proposed.