314-46-5

Basic information

• Product Name: 2-AMINO-6-(TRIFLUOROMETHYL)BENZOIC ACID
• Synonyms: BUTTPARK 24\07-93;2-AMINO-6-(TRIFLUOROMETHYL)BENZOIC ACID;6-(Trifluoromethyl)anthranilicacid;6-(Trifluoromethyl)anthranilic acid, 2-Carboxy-3-(trifluoromethyl)aniline, 3-Amino-2-carboxybenzotrifluoride;Benzoic acid, 2-amino-6-(trifluoromethyl)-
• CAS NO: 314-46-5
• Molecular Formula: C₈H₆F₃NO₂
• Molecular Weight: 205.13
• Product Categories: Benzoic acid;Fluorine series
• Mol File: 314-46-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: >202(subl.)
• Boiling Point: 296.6 °C at 760 mmHg
• Flash Point: 133.2 °C
• Appearance: /
• Density: 1.489
• Vapor Pressure: 0.000641mmHg at 25°C
• Refractive Index: 1.527
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.97±0.36(Predicted)
• CAS DataBase Reference: 2-AMINO-6-(TRIFLUOROMETHYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6-(TRIFLUOROMETHYL)BENZOIC ACID(314-46-5)
• EPA Substance Registry System: 2-AMINO-6-(TRIFLUOROMETHYL)BENZOIC ACID(314-46-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-37
• Hazardous Substances Data: 314-46-5(Hazardous Substances Data)

Usage

Uses

2-Amino-6-(trifluoromethyl)benzoic Acid is used in preparation of heterocyclyl substituted Acetamides as inhibitors of human immunodeficiency virus replication.

InChI:InChI=1/C8H6F3NO2/c9-8(10,11)4-2-1-3-5(12)6(4)7(13)14/h1-3H,12H2,(H,13,14)

Upstream product

• 256508-75-5 2-pivaloylamino-6-trifluoromethylbenzoic acid 
• 404-83-1 N-(3-trifluoromethylphenyl)-2-oxyiminoacetamide 
• 386-73-2 4-trifluoromethyl-1H-indole-2,3-dione 

Downstream Products

• 147494-56-2 methyl 2-amino-6-(trifluoromethyl)benzoate 
• 16499-63-1 4-chloro-5-(trifluoromethyl)quinazoline 
• 763027-00-5 (2-amino-6-(trifluoromethyl)phenyl)methanol 
• 959236-92-1 5-trifluoromethylquinazoline-2,4(1H,3H)-dione 
• 134517-56-9 2,4-dichloro-5-trifluoromethylquinazoline 
• 918667-28-4 2-amino-6-trifluoromethylbenzoic acid hydrochloride 
• 642491-87-0 8-trifluoromethyl-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-9-one 

Relevant articles and documents

METHOD FOR PRODUCING 4(3H)-QUINAZOLINONE DERIVATIVE

Disclosed is a method for producing 2-methyl-3-{4- [3-(1-pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone comprising a step for reacting 2-methyl-5-trifluoromethyl-4H-3,1-benzoxazine-4-one with 4-[3-(1-pirrolidinyl)propoxy]aniline or an acid addition salt thereof, or 4-(1-cyclobutyl-4-piperidinyl)oxyaniline or an acid addition salt thereof in the presence of an acetic acid catalyst.

Anthranilic acid derivatives

Agents for lowering glucose levels in blood having the formula: STR1 wherein Ro is bromo, chloro, fluoro, nitro or trifluoromethyl, R is hydrogen, C1-6 alkyl or C2-18 alkanoyl, and R1 is hydrogen or C1-12 alkyl, and the non-toxic, pharmaceutically acceptable salts thereof.