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404-83-1

2-Hydroxyimino-N-(3-trifluoromethyl-phenyl)-acetamide is a chemical compound with the molecular formula C9H7F3N2O2. It is an organic compound that features a trifluoromethyl-phenyl group attached to an acetamide moiety, which contains a hydroxyimino functional group. 2-HYDROXYIMINO-N-(3-TRIFLUOROMETHYL-PHENYL)-ACETAMIDE is known for its potential applications in the synthesis of pharmaceuticals and agrochemicals, particularly as a building block for the development of new molecules with biological activity. Its structure provides a unique combination of electronic and steric properties, which can influence its reactivity and interactions with other molecules, making it a valuable intermediate in organic synthesis.

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  • 404-83-1 Structure

  • Basic information

    1. Product Name: 2-HYDROXYIMINO-N-(3-TRIFLUOROMETHYL-PHENYL)-ACETAMIDE
    2. Synonyms: (2E)-2-hydroxyimino-N-[3-(trifluoromethyl)phenyl]acetamide
    3. CAS NO:404-83-1
    4. Molecular Formula: C9H7F3N2O2
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 404-83-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: °Cat760mmHg
    3. Flash Point: °C
    4. Appearance: /
    5. Density: 1.38g/cm3
    6. Refractive Index: 1.503
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-HYDROXYIMINO-N-(3-TRIFLUOROMETHYL-PHENYL)-ACETAMIDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-HYDROXYIMINO-N-(3-TRIFLUOROMETHYL-PHENYL)-ACETAMIDE(404-83-1)
    11. EPA Substance Registry System: 2-HYDROXYIMINO-N-(3-TRIFLUOROMETHYL-PHENYL)-ACETAMIDE(404-83-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 404-83-1(Hazardous Substances Data)

404-83-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 404-83-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,0 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 404-83:
(5*4)+(4*0)+(3*4)+(2*8)+(1*3)=51
51 % 10 = 1
So 404-83-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H7F3N2O2/c10-9(11,12)6-2-1-3-7(4-6)14-8(15)5-13-16/h1-5,16H,(H,14,15)/b13-5+

404-83-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(3-trifluoromethylphenyl)-2-oxyiminoacetamide

1.2 Other means of identification

Product number -
Other names 2-(hydroxyimino)-N-[3-(trifluoromethyl)phenyl]-acetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:404-83-1 SDS

404-83-1Relevant articles and documents

Novel synthesis of 4-or 6-substituted indirubin derivatives

Zhang, Aiying,Yu, Mingfeng,Lan, Tian,Liu, Zenglu,Mao, Zhenmin

experimental part, p. 3125 - 3134 (2010/12/24)

A simple and convenient route for synthesis of a series of 4-or 6-substituted indirubin derivatives by oxidation and subsequent condensation of indoxyl and isatin is described. Acidic reaction conditions are crucial to the condensation of 4-substituted derivatives, whereas for the condensation of 6-substituted derivatives, both acidic and basic conditions work well. Copyright Taylor & Francis Group, LLC.

3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically Active Anticonvulsants Acting by Antagonism at the Glycine Site of the N-Methyl-D-Aspartate Receptor Complex

Rowley, Michael,Leeson, Paul D.,Stevenson, Graeme I.,Moseley, Angela M.,Stansfield, Ian,et al.

, p. 3386 - 3396 (2007/10/02)

Most full antagonists at the glycine site of the NMDA receptor contain a carboxylic acid, which we believe to be detrimental to penetration of the blood-brain barrier.By consideration of a pharmacophore, novel antagonists at this site have been designed in which the anionic functionality is a vinylogous acid, in the form of a 4-hydroxyquinolin-2(1H)-one.In this series, a 3-substituent is necessary for binding, and correct manipulation of this group leads to compounds such as the 3-(3-hydroxyphenyl)propargyl ester 24 (L-701,273), with an IC50 for displacement of -L-689,560 binding of 0.17 μM and Kb against NMDA in the cortical slice of 1.39 μM.Compounds were tested for their ability to prevent audiogenic seizure in DBA/2 mice; the most potent compound in this series is the cyclopropyl ketone 42 (L-701,252), with an ED50 of 4.1 mg/kg ip.A model is proposed for binding to the glycine site, in which an important interaction is of a putative receptor cation with the ?-system of the 3-substituent.

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