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4-Hydroxy-3-iodo-5-nitro-benzaldehyde is an organic compound with the chemical formula C7H4INO4. It is a derivative of benzaldehyde, featuring a hydroxyl group (-OH) at the 4th position, an iodine atom (-I) at the 3rd position, and a nitro group (-NO2) at the 5th position. This yellow crystalline solid is known for its potential applications in the synthesis of pharmaceuticals and other organic compounds. Due to its reactive functional groups, it can participate in various chemical reactions, such as nucleophilic aromatic substitution, reduction, and condensation reactions. The compound is typically synthesized through a series of chemical reactions involving benzaldehyde and subsequent introduction of the hydroxy, iodo, and nitro groups. It is important to handle 4-hydroxy-3-iodo-5-nitro-benzaldehyde with care due to its potential reactivity and the presence of a nitro group, which can be sensitive to heat and shock.

3861-58-3

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3861-58-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3861-58-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,6 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3861-58:
(6*3)+(5*8)+(4*6)+(3*1)+(2*5)+(1*8)=103
103 % 10 = 3
So 3861-58-3 is a valid CAS Registry Number.

3861-58-3Relevant academic research and scientific papers

Preparation of the three C1-C7, C8-C15, and C16-N22 fragments of the Hsp90 inhibitor herbimycin A

Centonze-Audureau, Sylvie,Porée, Fran?ois-Hugues,Betzer, Jean-Fran?ois,Brion, Jean-Daniel,Pancrazi, Ange,Ardisson, Janick

, p. 981 - 985 (2007/10/03)

The construction of the three C16-N22 2, C1-C7 6 (as 23) and C8-C15 5 (as 32) segments of the Hsp90 inhibitor herbimycin A (1) is reported. l-Iodo-3-nitro-2,5-diphenol compound 2 was obtained in 55% yield for 3 steps from the commercially available diiodo derivative 7. Reaction between 1,1-dibromo-alkene 22 and vinyltin 17a using Pd(PPh3)4 or Pd(CH3CN)2Cl2/CuI/diisopropylethylamine, in toluene or DMF at 85 °C, led to enyne 23 in 63% yield (19% overall yield from isopropylidene glyceraldehyde). The synthesis of the C8-C15 sub-unit 32 was performed in 3.4% overall yield for 13 steps, from the commercially available ester 24, with a Hoppe crotylation as a key step.

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