1948-40-9

Basic information

• Product Name: 3,5-DIIODO-4-HYDROXYBENZALDEHYDE
• Synonyms: AKOS B028744;3,5-DIIODO-4-HYDROXYBENZALDEHYDE;4-HYDROXY-3,5-DIIODO-BENZALDEHYDE;3,5-Diiodo-4-Hydroxybenzaldhyde;3,5-DIIODO-4-HYDROXYBENZALDEHYDE, 98+%;2,6-Diiodo-4-formylphenol;NSC 72943;4-Hydroxy-3,5-diiodobenzaldehyde, 98+%
• CAS NO: 1948-40-9
• Molecular Formula: C₇H₄I₂O₂
• Molecular Weight: 373.91
• EINECS: 217-754-3
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Aromatics;Miscellaneous Reagents
• Mol File: 1948-40-9.mol
• Article Data: 19

Chemical Properties

• Melting Point: 202-203°C
• Boiling Point: 284.1°C at 760 mmHg
• Flash Point: 125.6°C
• Appearance: /
• Density: 2.602g/cm³
• Vapor Pressure: 0.00177mmHg at 25°C
• Refractive Index: 1.787
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly)
• PKA: 4.89±0.23(Predicted)
• Water Solubility: Insoluble in water. Sparingly soluble in chloroform and methanol.
• Sensitive: Air & Light Sensitive
• BRN: 1283414
• CAS DataBase Reference: 3,5-DIIODO-4-HYDROXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIIODO-4-HYDROXYBENZALDEHYDE(1948-40-9)
• EPA Substance Registry System: 3,5-DIIODO-4-HYDROXYBENZALDEHYDE(1948-40-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 1948-40-9(Hazardous Substances Data)

Usage

Chemical Properties

Pale Beige Solid

Uses

3,5-Diiodo-4-hydroxybenzaldehyde (cas# 1948-40-9) is a compound useful in organic synthesis.

InChI:InChI=1/C7H4I2O2/c8-5-1-4(3-10)2-6(9)7(5)11/h1-3,11H

Upstream product

• 67-66-3 chloroform 
• 28177-54-0 2,6-diiodo-phenol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 7553-56-2 iodine 
• 64-17-5 ethanol 
• 7782-68-5 iodic acid 
• 60032-63-5 4-hydroxy-3-iodo-benzaldehyde 
• 139-02-6 sodium phenoxide 
• 780-00-7 (4-hydroxy-3,5-diiodo-phenyl)-pyruvic acid 
• 37987-26-1 4-(hydroxymethyl)-2,6-diiodophenol 

Downstream Products

• 52273-39-9 4-acetoxy-3,5-diiodo-benzaldehyde 
• 56926-77-3 4-hydroxy-3,5-diiodo-trans-cinnamic acid 
• 855264-82-3 4-cyclohex-2-enyloxy-3,5-diiodo-benzaldehyde 
• 725252-79-9 3,5-diiodo-4-methoxy-benzaldehyde dimethylacetal 
• 93087-37-7 4-(4-acetoxy-3,5-diiodo-benzylidene)-2-methyl-4H-oxazol-5-one 
• 5051-60-5 N,N-Dimethyl-N'-(3,5-diiod-4-hydroxybenzyliden)-hydrazin 
• 596094-66-5 C₇H₄ClI₂NO₂ 
• 74478-58-3 phthalaldehydic acid phenylhydrazone 
• 588-64-7 (E)-1-benzylidene-2-phenylhydrazine 

Relevant articles and documents

NCBSI/KI: A Reagent System for Iodination of Aromatics through in Situ Generation of I-Cl

In situ iodine monochloride (I-Cl) generation followed by iodination of aromatics using NCBSI/KI system has been developed. The NCBSI reagent requires no activation due to longer bond length, lower bond dissociation energy, and higher absolute charge density on nitrogen. The system is adequate for mono- and diiodination of a wide range of moderate to highly activated arenes with good yield and purity. Moreover, the precursor N-(benzenesulfonyl)benzenesulfonamide can be recovered and transformed to NCBSI, making the protocol eco-friendly and cost-effective.

Efficient and sustainable laccase-catalyzed iodination of: P -substituted phenols using KI as iodine source and aerial O2 as oxidant

The laccase-catalyzed iodination of p-hydroxyarylcarbonyl- and p-hydroxyarylcarboxylic acid derivatives using KI as iodine source and aerial oxygen as the oxidant delivers the corresponding iodophenols in a highly efficient and sustainable manner with yields up to 93% on a preparative scale under mild reaction conditions.