386264-51-3 Usage
Explanation
The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 11 carbon atoms, 10 hydrogen atoms, 4 nitrogen atoms, and 3 oxygen atoms.
Explanation
A heterocyclic compound is a ring-shaped molecule containing atoms of different elements. In this case, the 1,2,3-triazole ring contains three nitrogen atoms and two carbon atoms.
Explanation
The carboxylic acid group is a functional group consisting of a carbon atom double-bonded to an oxygen atom and single-bonded to a hydroxyl group (-OH). It is present in 1-(3-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid, contributing to its potential pharmaceutical and biological activity.
Explanation
A methyl group is an alkyl group derived from methane, consisting of one carbon atom bonded to three hydrogen atoms. In 1-(3-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid, the methyl group is attached to the triazole ring.
Explanation
The methoxyphenyl group is an aryl group derived from anisole, consisting of a benzene ring with a methoxy group (-OCH3) attached to it. In 1-(3-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid, the methoxyphenyl group is attached to the triazole ring.
6. Pharmaceutical and biological activity
Explanation
The presence of the carboxylic acid, methyl, and methoxyphenyl groups in 1-(3-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid suggests that it may have potential pharmaceutical and biological activity. This makes it an interesting candidate for further study and potential use in drug development.
7. Derivative of 1,2,3-triazole
Explanation
1-(3-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid is a derivative of the 1,2,3-triazole ring, which is a five-membered heterocyclic compound containing three nitrogen atoms and two carbon atoms. The addition of the carboxylic acid, methyl, and methoxyphenyl groups to the triazole ring creates a unique chemical structure with potential applications in various fields.
Heterocyclic compound
1,2,3-triazole
Carboxylic acid group
-COOH
Methyl group
-CH3
Methoxyphenyl group
-OCH3
Check Digit Verification of cas no
The CAS Registry Mumber 386264-51-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,6,2,6 and 4 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 386264-51:
(8*3)+(7*8)+(6*6)+(5*2)+(4*6)+(3*4)+(2*5)+(1*1)=173
173 % 10 = 3
So 386264-51-3 is a valid CAS Registry Number.
386264-51-3Relevant academic research and scientific papers
Primary discovery of 1-aryl-5-substituted-1H-1,2,3-triazole-4-carboxamides as promising antimicrobial agents
Finiuk, Nataliya,Klyuchivska, Olha,Manko, Nazar,Matiychuk, Vasyl,Obushak, Mykola,Pokhodylo, Nazariy,Stoika, Rostyslav
, (2021/08/05)
Three series of novel 1H-1,2,3-triazole-4-carboxamides: 1-aryl-5-alkyl/aryl-1H-1,2,3-triazole-4-carboxamides, 1-aryl-5-amino-1H-1,2,3-triazole-4-carboxamides and 1,2,3-triazolo[1,5-a]quinazoline-3-carboxamides were synthesized via base-mediated click azide reactions. Compounds were evaluated for their antimicrobial activities against primary pathogens: Gram-positive and Gram-negative bacterial strains Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, as well as fungal strain Cryptococcus neoformans var. grubii and Candida albicans. Compounds exhibiting moderate to good activities were selected for SAR analysis. Several 5-methyl-1H-1,2,3-triazole-4-carboxamides 4d, 4l, 4r, showed potent antibacterial effect against S. aureus. On the contrary, 5-amino-1H-1,2,3-triazole-4-carboxamide 8b and [1,2,3]triazolo[1,5-a]quinazoline-3-carboxamide 9a were active against pathogenic yeast C. albicans. Thus, compound 4l under 1 μM demonstrated 50% growth inhibition against S. aureus. At the same concentration, the compound 9a killed approx. 40% of C. albicans cells. In general, these compounds demonstrated selective action and no significant impact on the viability of human keratinocytes of HaCaT line.
Synthesis of 1,2,4- and 1,3,4-oxadiazoles from 1-aryl-5-methyl-1H-1,2,3- triazole-4-carbonyl chlorides
Obushak,Pokhodylo,Pidlypnyi,Matiichuk
scheme or table, p. 1522 - 1527 (2009/06/28)
5-Substituted 2-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazoles were synthesized by reaction of 1-aryl-5-methyl-1H-1,2,3-triazole-4-carbonyl chlorides with the corresponding 5-substituted 1H-tetrazoles. 5-Methyl-1-phenyl-1H-1,2,3-triazole-4-carb
