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2',3'-O-isopropylidene-O2,5'-cyclouridine is a chemical compound derived from uridine, a nucleoside found in RNA. 2',3'-O-isopropylidene-O2,5'-cyclouridine is characterized by the presence of an isopropylidene group at the 2' and 3' positions of the ribose sugar, which protects the hydroxyl groups and prevents unwanted reactions. Additionally, the compound features a cyclized structure between the 2' and 5' positions, creating a unique cyclic nucleoside. This modification can affect the compound's stability, reactivity, and potential biological activity. It is often used in medicinal chemistry and chemical biology to study the effects of structural modifications on nucleosides and to develop new therapeutic agents.

3868-21-1

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3868-21-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3868-21-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,6 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3868-21:
(6*3)+(5*8)+(4*6)+(3*8)+(2*2)+(1*1)=111
111 % 10 = 1
So 3868-21-1 is a valid CAS Registry Number.

3868-21-1Relevant academic research and scientific papers

Synthesis of novel 5'-uridine-head amphiphiles as model for DNA molecular recognition

Tiecco, Matteo,Di Profio, Pietro,Germani, Raimondo,Savelli, Gianfranco

scheme or table, p. 911 - 923 (2010/09/04)

Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed as DNA transfection agents. The synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization that occurs when uridine is functionalized in this position without using protecting groups in the uracil.

Studies on Nucleosides and Nucleotides. XII. Carbon-Chain Extension at 5'-Position of of Ribonucleosides

Kimura, Junji,Kobayashi, Hideyuki,Miyahara, Osamu,Mitsunobu, Oyo

, p. 869 - 874 (2007/10/02)

2,6-Di-t-butyl-4-nitrophenol reacted O2-methyluridine, N3-methyluridine or 4-triazolyl-1-(β-D-ribofuranosyl)-2-(1H)-prymidinone in the presence of diethyl azodicarboxylate and triphenylphosphine selectively at the 5'-position to give

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