38696-75-2Relevant academic research and scientific papers
Synthesis and biological evaluation of 1,2,4,5-tetrasubstituted imidazoles
Fang, Yue,Yuan, Rui,Ge, Wen-hui,Wang, Yuan-jiang,Liu, Gui-xiang,Li, Ming-qi,Xu, Jiang-biao,Wan, Yu,Zhou, Sheng-liang,Han, Xi-guang,Zhang, Peng,Liu, Jin-juan,Wu, Hui
, p. 4413 - 4421 (2017)
Tetrasubstituted imidazoles were synthesized in high yields via the four-component reaction of aromatic aldehydes, amines, substituted benzils and ammonium acetate catalyzed by a porous CeO2 nanorod. Their anti-cancer activities on the Huh-7 hepatocellular carcinoma cell and antibacterial activities on four bacterial species (wild-type Escherichia coli, wild-type Staphylococcus aureus, Pseudomonas aeruginosa PAM1032 and Escherichia coli-NMD-1) in vitro were evaluated. One compound (5p) was screened out because of its high inhibition rate on all four bacterials at 100 μg/mL. Three products (5p, 5t and 5y) showed a high inhibition rate on the Huh-7 hepatocellular carcinoma cell at 10 μg/mL. The results indicated their potential in new drug development.
