387361-21-9

Basic information

• Product Name: 1-(4-(4-fluorophenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine
• Synonyms: 1-(4-(4-fluorophenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine
• CAS NO: 387361-21-9
• Molecular Weight: 249.312
• Mol File: 387361-21-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(4-(4-fluorophenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(4-fluorophenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine(387361-21-9)
• EPA Substance Registry System: 1-(4-(4-fluorophenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine(387361-21-9)

Safety Data

• Hazardous Substances Data: 387361-21-9(Hazardous Substances Data)

Upstream product

• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 1752-30-3 Acetone thiosemicarbazone 

Relevant articles and documents

Fluorine-containing compound and application thereof as antifungal drug

The invention discloses a fluorine-containing compound and application thereof as an antifungal drug. The invention claims to protect a compound as shown in a formula I or pharmaceutically acceptable salt, ester and solvate thereof. In the formula I, R is-NH2 or-N = C (CH3) 2. Compared with itraconazole, fluconazole and amphotericin B, the compound as shown in the formula I provided by the invention has a smaller MIC (Minimum Inhibitory Concentration) value, which shows that the compound has a more excellent antifungal effect.

Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies

Recently we described some (thiazol-2-yl)hydrazones as antiprotozoal, antifungal and anti-MAO agents as well as Gcn5 HAT inhibitors. Among these last compounds, CPTH2 and CPTH6 showed HAT inhibition in cells and broad anticancer properties. With the aim to identify HAT inhibitors more potent than the two prototypes, we synthesized several new (thiazol-2-yl)hydrazones including some related thiazolidines and pyrimidin-4(3H)-ones, and we tested the whole library existing in our lab against human p300 and PCAF HAT enzymes. Some compounds (1x, 1c', 1d', 1i' and 2m) were more efficient than CPTH2 and CPTH6 in inhibiting the p300 HAT enzyme. When tested in human leukemia U937 and colon carcinoma HCT116 cells (100 μM, 30 h), 1x, 1i' and 2m gave higher (U937 cells) or similar (HCT116 cells) apoptosis than CPTH6, and were more potent than CPTH6 in inducing cytodifferentiation (U937 cells).