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1752-30-3

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1752-30-3 Usage

Chemical Properties

Acetone thiosemicarbazide is a white to yellow crystalline solid

General Description

Solid.

Reactivity Profile

Acetone thiosemicarbazone may form toxic gases with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. May form flammable gases with alkali metals. Explosive combination may occur with strong oxidizing agents, metal salts, peroxides, and sulfides. Emits toxic fumes of oxides of sulfur and nitrogen when heated to decomposition [Sax, 9th ed., 1996, p. 3165].

Health Hazard

High oral toxicity.

Fire Hazard

When heated to decomposition, Acetone thiosemicarbazone emits very toxic fumes of nitrogen oxides and sulfur oxides. Avoid decomposing heat.

Potential Exposure

Acetone thiosemicarbazone is used as an intermediate in the manufacture of pharmaceuticals and pesticides. May be used as an agricultural chemical.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides

Check Digit Verification of cas no

The CAS Registry Mumber 1752-30-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,5 and 2 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1752-30:
(6*1)+(5*7)+(4*5)+(3*2)+(2*3)+(1*0)=73
73 % 10 = 3
So 1752-30-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H9N3S/c1-3(2)6-7-4(5)8/h1-2H3,(H3,5,7,8)

1752-30-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Acetone Thiosemicarbazone

1.2 Other means of identification

Product number -
Other names (propan-2-ylideneamino)thiourea

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1752-30-3 SDS

1752-30-3Relevant articles and documents

Growth dynamics and molecular structural analysis of Dimethylketo thiosemicarbazone single crystals for frequency conversion applications - Optical and thermal characterization

Sakunthaladevi,Jothi

, (2021)

New organic Schiff base of Dimethylketo thiosemicarbazone (DMKT) was synthesized by condensation process and grown by solvent slow evaporation method in methanol solution. The grown crystal was subjected to a single crystal and powder X-ray diffraction study and to identify that the material crystallized into a triclinic crystal system with a P-1 noncentrosymmetric space group. The X-Ray data reveals that the crystalline network cohesion of this compound. The FT-IR and FT Raman spectral analysis show the vibration behavior of chemical bonds in the grown material. Its optical behavior was examined by UV–VIS spectrum and the DMKT crystal was found to have transparency in the region between 350 nm and 1100 nm. The luminescent emission of the grown material was identified from the fluorescence spectrum. Improvement in the second harmonic generation efficiency of the grown material was studied by the Kurtz and Perry powder method and it shows 26.7 mV of green light emission. The thermal stability and melting point of DMKT were confirmed by various thermal analyses.

Novel 1,3-thiazolidin-4-one derivatives as promising anti- Candida agents endowed with anti-oxidant and chelating properties

Secci, Daniela,Carradori, Simone,Bizzarri, Bruna,Chimenti, Paola,De Monte, Celeste,Mollica, Adriano,Rivanera, Daniela,Zicari, Alessandra,Mari, Emanuela,Zengin, Gokhan,Aktumsek, Abdurrahman

, p. 144 - 156 (2016)

Pursuing our recent outcomes regarding the antifungal activity of N-substituted 1,3-thiazolidin-4-ones, we synthesized thirty-six new derivatives introducing aliphatic, cycloaliphatic and heteroaromatic moieties at N1-hydrazine connected with C2 position of the thiazolidinone nucleus and functionalizing the lactam nitrogen with differently substituted (NO2, NH2, Cl and F) benzyl groups. These compounds were tested to evaluate their minimum inhibitory concentration (MIC) against several clinical Candida spp. with respect to topical and systemic reference drugs (clotrimazole, fluconazole, ketoconazole, miconazole, tioconazole, amphotericin B). Moreover, anti-oxidant properties were also evaluated by using different protocols including free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), metal chelating and phosphomolybdenum assays. Moreover, for the most active derivatives we assessed the toxicity (CC50) against Hep2 human cells in order to characterize them as multi-target agents for fungal infections.

Synthesis, spectra and crystal structure of two copper(I) complexes of acetonethiosemicarbazone

Lhuachan, Sanchai,Siripaisarnpipat, Sutatip,Chaichit, Narongsak

, p. 263 - 267 (2003)

The reaction of copper(I) chloride with acetonethiosemicarbazone (tscac) in a copper to tscac molar ratio of 1:2 forms the cationic complex [Cu(tscac)2]Cl (1). When the ratio of the copper to tscac was reduced to 1:1, a dimeric complex [Cu2Cl2(tscac)2]2 (2) was obtained. In complex 2, two CuCl2 species act as bridging groups between two Cu(tscac)2 moieties forming an eight-membered ring, whereas in complex 1, there is no CuCl2 moiety in the structure. In both complexes the copper(I) center is coordinated in a distorted tetrahedral geometry to two tscac groups through the sulfur and the imine nitrogen atom. In dimeric complex 2, the sulfur atom in each tscac ligand coordinates weakly to copper(I) in the CuCl2 moiety giving the distorted tetrahedral geometry. For the free ligand, the vc=s vibration at 789 cm-1 appears at lower energy than in complexes 1 and 2 (754 and 744 cm-1 respectively) indicating coordination at the sulfur atom. The complexes synthesized by either electrochemical or chemical methods are identical. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF

-

Page/Page column 22-23; 28; 32, (2020/06/22)

The present application relates to novel semicarbazones and thiosemicarbazones, to processes for preparing them, to pharmaceutical preparations comprising them, to the use of the novel semicarbazones and thiosemicarbazones for treatment and/or prophylaxis of diseases and to the use thereof for production of a medicament for treatment and/or prophylaxis of diseases, especially of neurodegeneration and age-associated diseases or conditions associated with NAD loss. The present application also provides a method for high throughput screening of NMNAT2 activators.

THIAZOLE DERIVATIVE AND APPLICATIONS

-

Paragraph 0091-0092, (2019/04/16)

A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.

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