38759-59-0

Upstream product

• 1417600-63-5 N-(diphenylmethylene)pent-4-yn-1-amine 
• 1013-88-3 Benzophenone imine 
• 1417600-62-4 C₃₀H₄₅NSn 
• 1417600-61-3 (2E,4S,5S,8E)-ethyl 8-(1-benzhydrylpyrrolidin-2-ylidene)-4-((tert-butyldimethylsilyl)oxy)-5-methyl-7-oxooct-2-enoate 
• 616-45-5 2-pyrrolidinon 
• 776-74-9 Bromodiphenylmethane 

Downstream Products

• 1354577-59-5 tert-butyl (R)-1-benzhydryl-3-benzyl-2-oxopyrrolidine-3-carboxylate 
• 1354577-54-0 N⁽¹⁾-benzhydryl-2-pyrrolidinone-3-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Enantioselective Total Synthesis of Nitraria Alkaloids: (+)-Nitramine, (+)-Isonitramine, (-)-Isonitramine, and (-)-Sibirine via Asymmetric Phase-Transfer Catalytic α-Allylations of α-Carboxylactams

Many optically active 2-azaspirocyclic structures have frequently been found in biologically active natural products. In particular, Nitraria alkaloids, (+)-nitramine, (+)-isonitramine, (-)-isonitramine, and (-)-sibirine, have stereogenicity on their quat

Total synthesis of the lycopodium alkaloid serratezomine a using free radical-mediated vinyl amination to prepare a β-stannyl enamine linchpin

Serratezomine A is a member of the structurally diverse class of compounds known as the Lycopodium alkaloids. The key supporting studies and successful total synthesis of serratezomine A are described in this account. Significant features of the synthesis include the first application of free radical mediated vinyl amination and Hwu's oxidative allylation in a total synthesis and an intramolecular lactonization via a transannular SNi reaction. Minimal use of protecting groups and the highly diastereoselective formation of a hindered, quaternary stereocenter using an umpolung allylation are also highlights from a strategy perspective. Observation of quaternary carbon epimerization via a retro-Mannich/Mannich sequence highlights the additional challenge presented by the axial alcohol at C8 in serratezomine A.

Highly enantioselective phase-transfer catalytic α-alkylation of α-tert-butoxycarbonyllactams: Construction of β-quaternary chiral pyrrolidine and piperidine systems

A new enantioselective α-alkylation of α-tert- butoxycarbonyllactams for the construction of β-quaternary chiral pyrrolidine and piperidine core systems is reported. α-Alkylations of N-methyl-α-tert-butoxycarbonylbutyrolactam and N-diphenylmethyl-α- tert-