387827-19-2

Basic information

• Product Name: 4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 4-(3-AMINOPHENYL)PIPERIDINE-1-CARBOXYLATE;N-BOC-4-(3-AMINOPHENYL) PIPERIDINE;1-Piperidinecarboxylic acid, 4-(3-aMinophenyl)-, 1,1-diMethylethyl ester;Tert-butyl 4-[3-(amino)phenyl]-1-Piperidinecarboxylate;tert-Butyl 4-(3-aminophenyl)
• CAS NO: 387827-19-2
• Molecular Formula: C₁₆H₂₄N₂O₂
• Molecular Weight: 276.37
• Product Categories: pharmacetical
• Mol File: 387827-19-2.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 413.217°C at 760 mmHg
• Flash Point: 203.706°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.60±0.10(Predicted)
• CAS DataBase Reference: 4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(387827-19-2)
• EPA Substance Registry System: 4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(387827-19-2)

Safety Data

• Hazardous Substances Data: 387827-19-2(Hazardous Substances Data)

Usage

General Description

4-(3-Amino-phenyl)-piperidine-1-carboxylic acid tert-butyl ester is a chemical compound with the molecular formula C18H27N3O2. It is a derivative of piperidine, a heterocyclic organic compound. This chemical is often used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Its tert-butyl ester group makes it more stable and less reactive, allowing for easier storage and handling. It also has potential applications in research and development in the pharmaceutical and biotechnology industries. Overall, 4-(3-Amino-phenyl)-piperidine-1-carboxylic acid tert-butyl ester is a versatile compound with various potential uses in the field of organic chemistry.

InChI:InChI=1/C16H24N2O2/c1-16(2,3)20-15(19)18-9-7-12(8-10-18)13-5-4-6-14(17)11-13/h4-6,11-12H,7-10,17H2,1-3H3

Upstream product

• 387827-18-1 tert-butyl 4-[3-(amino)phenyl]-1,2,3,6-tetrahydro-1-pyridinecarboxylate 
• 75-31-0 isopropylamine 
• 585-79-5 m-nitrobromobenzene 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 591-19-5 m-Bromoaniline 
• 1510865-58-3 tert-butyl 4-(3-nitrophenyl)piperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 138647-55-9 tert-butyl 1,2,3,6-tetrahydro-4-(3-nitrophenyl)pyridine-1-carboxylate 

Downstream Products

• 291289-49-1 4-(3-aminophenyl)piperidine 
• 387827-31-8 4-(3-isobutyrylaminophenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 387827-24-9 tert-butyl 4-[3-(acetylamino)-phenyl]-1-piperidinecarboxylate 

Relevant articles and documents

BRAF DEGRADERS

Present invention provides compounds that cause specifically the degradation of BRAF. The present compounds are useful for the treatment of various cancers.

Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

The expedient synthesis of compounds enriched in sp3 character is key goal in modern drug discovery. Herein, we report how a single pot Suzuki-Miyaura-hydrogenation can be used to furnish lead and fragment-like products in good to excellent yields. The approach has been successfully applied in formats amenable to parallel synthesis, in an asymmetric sense, and in the preparation of molecules with annotated biological activity.

PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES

This application relates to compounds of the general Formula I and salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.