388-03-4Relevant academic research and scientific papers
Multicomponent synthesis and anticancer activity studies of novel 6-(Trifluoromethyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate derivatives
Valeru, Anil,Luo, Zhi-Bin,Khan, Imran,Liu, Bin,Sngepu, Bhavanarushi,Godumagadda, Narender Reddy,Xu, Yin,Xie, Jimin
, p. 2226 - 2231 (2018)
A series of novel 6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives were obtained in good yields from ethyl 4,4,4-trifluoro-3-oxobutanoate, urea, and aryl aldehyde via Biginelli multicomponent reaction. All the corresponding products 4a–4p were examined against four human cancer cell lines (A549, HepG2, COLO205 and DU145) and compounds 4e, 4i, and 4 m which showed promising anticancer activity have been identified.
Ultrasound-accelerated synthesis of 3,4-dihydropyrimidin-2(1H)-ones with ceric ammonium nitrate
Yadav,Reddy,Reddy,Raj,Prasad
, p. 1939 - 1941 (2007/10/03)
Ceric ammonium nitrate efficiently catalyzes the three component condensation of an aldehyde, β-ketoester and urea in methanol to afford the corresponding dihydropyrimidinones in excellent yields under sonication. Other oxidants such as manganese triaceta
