3880-50-0

Usage

Uses

Used in Pharmaceutical Industry:
1-Methylethylidene hydrazine carboxaldehyde is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of diverse medicinal compounds with potential applications in treating a range of health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Methylethylidene hydrazine carboxaldehyde is utilized as an intermediate in the production of various agrochemicals, including pesticides and herbicides. Its role in the synthesis of these compounds helps to enhance crop protection and increase agricultural productivity.
Used as a Synthetic Building Block:
1-Methylethylidene hydrazine carboxaldehyde is employed as a synthetic building block for the creation of a wide array of organic compounds. Its versatile chemical properties enable the development of new materials and compounds with various applications across different industries, such as chemical manufacturing, materials science, and research.

Upstream product

• 67-64-1 acetone 
• 624-84-0 formic acid hydrazide 

Relevant academic research and scientific papers

Synthesis and characterization of acetone hydrazones

1-Isopropylidene-2-methylhydrazine (1), 1-isopropylidene-2- hydroxyethylhydrazine (2) and 1-isopropylidene-2-formylhydrazine (3) were synthesized by reaction of the corresponding hydrazine with an excess of acetone in the presence of a drying agent (anhydrous sodium sulfate or barium oxide). All compounds 1-3 were characterized by elemental analysis, coupled gas chromatography-mass spectrometry (GC-MS), multinuclear NMR spectroscopy ( 1H, 13C and 15N) and vibrational spectroscopy (infrared and Raman). Compounds 1 and 2 are liquid at room conditions and their density was measured by means of a picnometer, however, (at room conditions) compound 3 is a solid and its crystal density and structure were determined by low temperature X-ray diffraction techniques (monoclinic, P21/n, Z = 4, a = 5.666(1) A, b = 6.254(1) A, c = 15.277(4) A, β = 91.30(2)°, V = 541.2(2) A3). The structure of hydrazone 3 is discussed in detail and compared to that of monoformylhydrazine. Finally, the (gas phase) structure of compound 3 was optimized using DFT calculations (B3LYP/6-31+G(d, p)) and its NBO charges are reported. Copyright

New straightforward synthesis and characterization of a unique 1β- methylcarbapenem antibiotic biapenem bearing a σ-symmetric bicyclotriazoliumthio group as the pendant moiety

Biapenem 1, (1R,5S,6S,)-2-[(6,7-dihydro-5H-pyrazolo[1,2- α][1,2,4]triazolium-6-yl)thio]-6-yl)thio]-6-[(R)-1-hydroxyethyl]-1- methylcarbapen-2-em-3-carboxylate, is a new non-natural 1β-methylcarbapenem antibiotic which exhibits a wide range of antibacterial activity, remarkable chemical stability, and extensive stability against human renal dehydropeptidase-I. Mercaptobicyclotriazolium chloride 2 useful for the pendant moiety of 1 was successfully synthesized starting from hydrazine hydrate 3 along an economically available synthetic route. The thiol 2 was efficiently exploited for an expeditious synthesis of biapenem 1. Characterization (crystal structure, nonbonded S- - -O interaction, conformational analysis, and CH- - -O hydrogen bonds) of 1 was investigated by its X-ray crystallographic, 1H NMR, and deuteration experiment analyses.