388072-09-1

Basic information

• Product Name: (3-METHYL-2-FURYL)METHYLAMINE
• Synonyms: (3-METHYL-2-FURYL)METHYLAMINE;2-(Aminomethyl)-3-methylfuran;(3-Methylfur-2-yl)methylamine;(3-Methylfur-2-yl)methylamine, 3-Methylfurfurylamine;(3-Methylfuran-2-yl)MethanaMine
• CAS NO: 388072-09-1
• Molecular Formula: C₆H₉NO
• Molecular Weight: 111.14
• Mol File: 388072-09-1.mol

Chemical Properties

• Boiling Point: 167.3°Cat760mmHg
• Flash Point: 55°C
• Appearance: /
• Density: 1.024g/cm³
• Vapor Pressure: 1.71mmHg at 25°C
• Refractive Index: 1.498
• PKA: 9.16±0.29(Predicted)
• CAS DataBase Reference: (3-METHYL-2-FURYL)METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-METHYL-2-FURYL)METHYLAMINE(388072-09-1)
• EPA Substance Registry System: (3-METHYL-2-FURYL)METHYLAMINE(388072-09-1)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 388072-09-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(3-METHYL-2-FURYL)METHYLAMINE is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to be incorporated into complex molecular structures.
Used in Antiprion Applications:
(3-METHYL-2-FURYL)METHYLAMINE is used as a precursor for the preparation of thiazolecarboxylic acid amides and thiadiazole derivatives, which exhibit antiprion activity. These compounds are being investigated for their potential to treat prion-related diseases, such as Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.

InChI:InChI=1/C6H9NO/c1-5-2-3-8-6(5)4-7/h2-3H,4,7H2,1H3

Upstream product

• 6141-57-7 methyl 3-methylfuran-2-carboxylate 
• 84374-70-9 3-methyl-2-furancarboxamide 

Downstream Products

• 1231245-45-6 N-((3-methylfuran-2-yl)methyl)benzamide 
• 1418192-75-2 C₂₄H₂₁N₃O₃ 
• 1253298-99-5 N-[(3-methylfuran-2-yl)methyl]-2,4-diphenylthiazole-5-carboxamide 
• 1007604-36-5 benzyl (3-methylfuran-2-yl)methylcarbamate 

Relevant articles and documents

The Influence of Substitution on Thiol-Induced Oxanorbornadiene Fragmentation

Oxanorbornadienes (ONDs) undergo facile Michael addition with thiols and then fragment by a retro-Diels-Alder (rDA) reaction, a unique two-step sequence among electrophilic cleavable linkages. The rDA reaction rate was explored as a function of the furan

Synthesis of N -Acyl-5-aminopenta-2,4-dienals via base-induced ring-opening of N -acylated furfurylamines: Scope and limitations

N-Acylation of furfurylamines provided 1, which on double deprotonation with LDA led to the formation of N-acyl-5-aminopenta-2,4-dienals 2 via an isomerization involving opening of the furan ring. The scope and limitations of the procedure were examined by considering the influence of substituents on the carbonyl group and also on the heterocycle moiety. The efficacy of the reaction was shown to be very dependent on the nature of these groups.

Practical, scalable, high-throughput approaches to η3- pyranyl and η3-pyridinyl organometallic enantiomeric scaffolds using the achmatowicz reaction

(Figure Presented) A unified strategy for the high-throughput synthesis of multigram quantities of the η3-oxopyranyl- and η3-oxopyridinylmolybdenum complexes TpMo(CO)2(η 3-oxopyranyl) and TpMo(CO)2(η3- oxopyridinyl) is described (Tp = hydridotrispyrazolylborato). The strategy uses the oxa- and aza-Achmatowicz reaction for the preparation of these organometallic enantiomeric scaffolds, in both racemic and high enantiopurity versions.

Anti-Helicobacter pylori agents. 3. 2-[(Arylalkyl)guanidino]-4- furylthiazoles

A series of 2-[(arylalkyl)guanidino]-4-[(5-acetamidomethyl)furan-2- yl]thiazoles and some 4-acetamidomethyl positional isomers were synthesized and evaluated for antimicrobial activity against Helicobacter pylori. Among the compounds that had potent antim