38824-13-4Relevant academic research and scientific papers
Palladium Catalyzed Direct Acylation of Iodo-Acetanilides/Iodo-Phenyl Acetates: Domino One-Pot Synthesis of 2-Quinolinones
Basuli, Scuhand,Satyanarayana, Gedu
, p. 957 - 970 (2017/12/07)
Pd-catalyzed direct acylation reaction of iodoacetanilides/iodophenyl acetates with aldehydes is presented. Simple, bench-top aldehydes were used as non-toxic acylating agents. This protocol comprises direct coupling with aldehydes without activating the carbonyl group and without directing group assistance. The strategy was applied to a domino one-pot synthesis of 2-quinolinones through acylation and intramolecular aldol condensation. Significantly, the strategy was extended to the domino one-pot synthesis of drugs and bioactive compounds.
Palladium-catalyzed direct addition of arylboronic acids to 2-aminobenzonitrile derivatives: Synthesis, biological evaluation and in silico analysis of 2-aminobenzophenones, 7-benzoyl-2-oxoindolines, and 7-benzoylindoles
Chen, Jiuxi,Ye, Leping,Su, Weike
supporting information, p. 8204 - 8211 (2015/01/08)
A palladium-catalyzed direct addition of arylboronic acids to unprotected 2-aminobenzonitriles has been developed, leading to a wide range of 2-aminobenzophenones with moderate to excellent yields. The transformation has broad scope and high functional group tolerance. Moreover, 2-oxoindoline-7-carbonitrile and indole-7-carbonitrile were applicable to this process for the construction of 7-benzoyl-2-oxoindolines and 7-benzoylindoles, respectively. Among the compounds examined, compound 4e possessed the most potent anticancer activity against H446 and HGC-27 in vitro, with IC50 values of 0.02 μmol L-1 and 0.09 μmol L-1, respectively, while compound 4a showed the best potent anticancer activity against SGC-7901 with an IC50 value of 0.01 μmol L-1. Furthermore, we also performed in silico molecular docking calculations to investigate the interaction mode and binding affinity between the examined compounds and their tubulin target. This journal is
Efficient one-pot Friedel-Crafts acylation of benzene and its derivatives with unprotected aminocarboxylic acids in polyphosphoric acid
Ivanov, Iliyan,Nikolova, Stoyanka,Statkova-Abeghe, Stela
, p. 1405 - 1411 (2007/10/03)
A number of aminobenzophenones have been synthesized by acylation of benzene and its derivatives with different 2-,3-,4-aminobenzoic and 4-aminophenyl-acetic acids in polyphosphoric acid via Friedel-Crafts reaction as compounds with expected antitumor activity. Copyright Taylor & Francis Group, LLC.
Perchloric Acid-Acetic Acid Mixture as a Reagent for Detosylation of 2-N-p-Toluenesulphonylaminophenyl(phenyl)methanones
Wakankar, D. M.,Hosangadi, B. D.
, p. 223 - 224 (2007/10/02)
Perchloric acid-acetic acid mixture has been found to be an efficient reagent for the detosylation of various 2-N-p-toluenesulphonylaminophenyl(phenyl)methanones (1a-f).
