38847-77-7

Upstream product

• 5400-92-0 3-dimethylamino-2-methyl-1-phenyl-propan-1-one; hydrochloride 
• 26171-50-6 (S)-3-dimethylamino-2-methyl-1-phenyl-propan-1-one 
• 100-52-7 benzaldehyde 
• 108471-82-5 N,N,2-trimethyl-3-oxo-3-phenylpropanamide 
• 5309-94-4 N,N-Dimethyl-thiopropionamide 
• 76454-71-2 (2S,3S)-3-Hydroxy-2,N,N-trimethyl-3-phenyl-thiopropionamide 
• 20428-71-1 (2RS,3RS)-3-hydroxy-N,N,2-trimethyl-3-phenylpropanamide 
• 76454-71-2 (2S,3R)-3-Hydroxy-2,N,N-trimethyl-3-phenyl-thiopropionamide 
• 20428-71-1 threo-3-hydroxy-3-phenyl-2,N,N-trimethylpropionamide 
• 91-03-2 3-dimethylamino-2-methyl-1-phenyl-propan-1-one 

Downstream Products

• 29925-85-7 phenoxy-acetic acid-(3-dimethylamino-2-methyl-1-phenyl-propyl ester) 
• 23631-08-5 3-dimethylamino-2-methyl-1-phenyl-1-propene 

Relevant academic research and scientific papers

One-pot highly stereoselective reduction of β-keto amides to syn-γ-aminols

In the presence of titanium tetrachloride, the borane/tetrahydrofuran complex can reduce 2-methyl-3-oxoamides into the corresponding syn-aminols in good yields and high diastereoselectivity. The use of borane/dimethyl sulfide instead of BH3/THF

SUR LES ORGANOMETALLIQUES ISSUS DE THIOAMIDES. I. REACTIVITE AVEC LES ALDEHYDES ET CETONES; STEREOCHIMIE DE LA CONDENSATION AVEC LA t-BUTYL-4 CYCLOHEXANONE ET LE BENZALDEHYDE

Organometallic compounds derived from thioamides RCH2CSN(R3)2 condense normally with aldehydes and saturated ketones.Condensation with 4-t-butylcyclohexanone leads predominantly to equatorial attack by the organometallic compound.These results suggest that the organometallic structure is RCH=C(SM)N(R3)2.The stereoselectivity of the reaction with benzaldehyde depends on R and R3; a mechanism for the formation of β-hydroxythioamides is discussed.