5400-92-0

Usage

InChI:InChI=1/C12H17NO.ClH/c1-10(9-13(2)3)12(14)11-7-5-4-6-8-11;/h4-8,10H,9H2,1-3H3;1H

Upstream product

• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 93-55-0 1-phenyl-propan-1-one 
• 30354-18-8 N,N-dimethyl(methylene)ammonium chloride 

Downstream Products

• 74172-66-0 1-Dimethylamino-2,4-dimethyl-3-phenylpentan-3-ol 
• 243445-16-1 2-(2-methyl-3-oxo-3-phenyl-propyl)-cyclohexanone 
• 1253196-10-9 1-(N-methylthiocarbamoyl)-3-phenyl-4-methyl-4,5-dihydropyrazole 
• 102361-36-4 β-dimethylamino-α-methylpropiophenone 2,4,6-triisopropylbenzenesulphonylhydrazone 
• 611-70-1 phenyl isopropyl ketone 
• 74184-99-9 threo-3-Hydroxy-2-methyl-3-phenylpropyltrimethylammoniumiodid 
• 74184-99-9 erythro-3-Hydroxy-2-methyl-3-phenylpropyltrimethylammoniumiodid 
• 100-52-7 benzaldehyde 
• 74172-70-6 3-Hydroxy-2,4-dimethyl-3-phenylpentyltrimethylammoniumiodid 
• 65117-75-1 methyl 4-methyl-5-phenyl-1H-pyrrole-2-carboxylate 
• 888955-68-8 1-thiocarbamoyl-3-phenyl-4-methyl-4,5-dihydropyrazole 
• 129286-87-9 5,6-Dihydro-2,3-diphenyl<1,10>phenanthroline 
• 129286-89-1 2-methyl-3-phenyl-4,5-diazafluoren 
• 769-60-8 2-methyl-1-phenylprop-2-en-1-one 

Relevant academic research and scientific papers

Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase

Some differently substituted 3-aryl-4,5-dihydropyrazoles-1-carbothioamides have been synthesised with the aim to investigate their monoamine oxidase inhibitory activity. The chemical structures of the compounds have been characterized by means of their IR, 1H NMR, 13C NMR spectroscopic data and elemental analyses. All the active compounds showed a selective activity towards the B isoform of the enzyme, regardless of the substitution on the heterocyclic ring. The inhibition of the enzymatic activity was measured on human recombinant MAO isoforms, expressed in baculovirus infected BTI insect cells. Docking experiments were carried out with the aim to rationalize the mechanism of inhibition of the most active and selective compound.

Synthesis, characterization and antiamoebic activity of 1-(thiazolo[4,5-b]quinoxaline-2-yl)-3-phenyl-2-pyrazoline derivatives

A new series of 1-N-thiocarboxamide-3-phenyl-2-pyrazolines 1-6 was synthesized by cyclization of different Mannich bases with unsubstituted thiosemicarbazide. The reaction of cyclized pyrazoline derivatives 1-6 with 2,3-dichloroquinoxaline afforded the title compounds 7-12. The structures of the new compounds were confirmed by elemental analyses as well as 1H, 13C NMR, IR and electronic spectral data. The HM1:IMSS strain of Entamoeba histolytica parasite was cultured in vitro and the sensitivity of the parasite to the synthesized compounds was evaluated using the microdilution method. Among all the pyrazoline derivatives 1-6, none was found to be a better inhibitor as compared to the reference drug, metronidazole. The quinoxaline derivatives, 9, 11 and 12 were found to be potent inhibitors of E. histolytica.

Efficient Preparation of Substituted 5,6,7,8-Tetrahydroquinolines and Octahydroacridine Derivatives

The reaction of the enamine 4 with different β-amino ketone hydrochlorides 3a-e affords the diketones 5a-e which can be cyclized to the corresponding mono- and disubstituted tetrahydroquinolines 6a-e. Furthermore the preparation of the octahydroacridines 8f and 8g by using a straightforward multi step sequence is described.

β-Amino Ketones as Key Intermediates in the Synthesis of Pyridines: A Novel and Efficient Route to Annelated Bi- and Terpyridines

The hydrochlorides of β-amino ketones 1a-e (Mannich bases) are easily obtained starting compounds for a novel synthesis of pyridines.Condensation with the heteroaromatic ketones 8, 9, and 10 yields 5,6-dihydro-1,10-phenanthrolines 3a-d, 13 and 4,5-diazafluorenes 4a-d, which have not yet been described in literature.Symmetrical terpyridines 3e, 4e are formed in a one-step reaction of 8, 9 with dimethylmethylenammonium chloride in the presence of an ammonia source.