388597-75-9Relevant academic research and scientific papers
Synthesis and evaluation of nonpeptide substituted spirobenzazepines as potent vasopressin antagonists
Xiang, Min Amy,Chen, Robert H.,Demarest, Keith T.,Gunnet, Joseph,Look, Richard,Hageman, William,Murray, William V.,Combs, Donald W.,Rybczynski, Philip J.,Patel, Mona
, p. 3143 - 3146 (2007/10/03)
A series of substituted spirobenzazepines was prepared and evaluated as V1a and V2 dual vasopressin receptor antagonists. Compounds 7p and 7q have been shown to be not only potent inhibitors of vasopressin receptors, but also have exhibited an excellent overall pharmaceutical suitability profile.
