38873-94-8Relevant academic research and scientific papers
Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily
Van Loo, Bert,Bayer, Christopher D.,Fischer, Gerhard,Jonas, Stefanie,Valkov, Eugene,Mohamed, Mark F.,Vorobieva, Anastassia,Dutruel, Celine,Hyv?nen, Marko,Hollfelder, Florian
, p. 370 - 387 (2019)
Highly proficient, promiscuous enzymes can be springboards for functional evolution, able to avoid loss of function during adaptation by their capacity to promote multiple reactions. We employ a systematic comparative study of structure, sequence, and sub
Butyrylcholinesterase Inhibitors
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Paragraph 0126, (2016/08/17)
Butyrylcholinesterase inhibitors, their formulation, and their use primarily in the treatment of neurodegenerative diseases. These inhibitors generally are phosphates, phosphonates, phosphinates, and phosphoramidates. These inhibitors can be incorporated
Synthesis and anti-acetylcholinesterase properties of novel β- And γ-substituted alkoxy organophosphonates
Kaleem Ahmed,Belabassi, Yamina,Sankaranarayanan, Lakshmi,Chao, Chih-Kai,Gerdes, John M.,Thompson, Charles M.
, p. 2048 - 2051 (2013/04/23)
Activated organophosphate (OP) insecticides and chemical agents inhibit acetylcholinesterase (AChE) to form OP-AChE adducts. Whereas the structure of the OP correlates with the rate of inhibition, the structure of the OP-AChE adduct influences the rate at
