38940-18-0Relevant academic research and scientific papers
Heteropoly acid in ionic liquid - An efficient and recyclable system for one-pot three-component Mannich reaction
Rasalkar, Maghana S.,Bhilare, Sachin V.,Deorukhkar, Amol R.,Darvatkar, Nitin B.,Salunkhe, Manikrao M.
, p. 77 - 80 (2007)
This paper describes a one-pot three-component Mannich reaction, catalyzed by phosphotungstic acid (H3PW12O40), a heteropoly acid in ionic liquid. The catalyst was found to be mild and efficient, and the protocol affords β-arnino ketones in good yields under ambient conditions. Several ionic liquids and conventional organic solvents were employed for the reaction. The ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4) offered the best results in terms of yield of the products. It was observed that a Homogeneous reaction medium proved beneficial for the yield of the reaction.
A novel trypsin-catalyzed three-component mannich reaction
Chai, She-Jie,Lai, Yi-Feng,Zheng, Hui,Zhang, Peng-Fei
experimental part, p. 2231 - 2236 (2011/02/16)
We found that the trypsin from hog pancreas displayed high activity to promote three-component Mannich reaction of aromatic aldehydes, aromatic amines, and acetone with moderate-to-excellent yields. The reaction tolerates a great range of substrates and e
