38946-46-2

Usage

Molar mass

311.15 g/mol

Type of compound

Phenolic

Substituents on benzene ring

tert-Butyl group, iodine atom

Amino group attachment

Connected to benzene ring through a methylene bridge

Uses

Organic synthesis, pharmaceutical research (building block for synthesis of various compounds)

Hazards

Potential health and environmental risks (handle with caution)

Upstream product

• 63712-10-7 N-(5-tert-Butyl-2-hydroxy-3-iodo-benzyl)-2-chloro-acetamide 
• 869953-38-8 N-(5-tert-Butyl-2-hydroxy-benzyl)-2-chloro-acetamide 
• 38941-98-9 4-tert-butyl-2-iodophenol 
• 98-54-4 para-tert-butylphenol 
• 63712-11-8 2-aminomethyl-4-tert-butyl-phenol; hydrochloride 

Downstream Products

• 81440-92-8 1-<<<5-(1,1-dimethylethyl)-2-hydroxy-3-iodophenyl>methyl>amino>tetrazole 
• 81441-05-6 4-tert-Butyl-2-iodo-6-[(E)-methyliminomethyl]-phenol 
• 81440-93-9 4-(1,1-dimethylethyl)-2-<(methylamino)methyl>-6-iodophenol 
• 71064-03-4 5-(1,1-dimethylethyl)-3-iodosalicylaldehyde 
• 81440-87-1 N-<<5-(1,1-dimethylethyl)-2-hydroxy-3-iodophenyl>methyl>urea 

Relevant academic research and scientific papers

2-(Aminomethyl)phenols, a new class of saluretic agents. I. Effect of nuclear substitution

A series of 2-(aminomethyl)phenols was synthesized and tested in rats and dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration. The most active compounds belong to a subseries of 4-alkyl-6-halo derivatives of which 2,2(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenyl, is the most active. Compound 2 also possesses significant antihypertensive activity, an adjunctive pharmacological parameter which distinguishes 2 from the other compounds prepared in this series. In addition, 2 displays both topical saluretic and antiinflammatory activities.

Substituted 2-aminomethyl-6-iodophenols

Certain substituted 2-aminomethyl-6-iodophenols and their pharmaceutically acceptable acid addition salts wherein the phenyl nucleus may be further substituted with 1 to 3 nuclear substituents are useful as antihypertensive, diuretic and saluretic agents.