71064-03-4Relevant academic research and scientific papers
A Novel Synthesis of 2-Ferrocenoyl-Substituted Iodobenzofurans
Li, Yang,Zhuoma, Bairenqing,Gao, Wentao
, p. 764 - 768 (2017)
In the present investigation, the first construction of a series of structurally new 2-ferrocenoyl-substituted iodobenzofurans hybrids has been achieved through a simple and mild two-step procedure, involving the iodination of salicylaldehydes using N-iodosuccinimide reagent in eco-friendly PEG-400 medium at room temperature followed by one-pot Rap–Stoermer reaction with 1-chloroacetylferrocene in refluxing MeCN with the presence of K2CO3as base and PEG-400 as the activated additive. These newly synthesized compounds belong to a new class of ferrocene-benzofuran hybrids and could be good candidates for the development of compounds for use in medicinal chemistry.
2-Hydroxylaminomethyl phenols
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, (2008/06/13)
It has been found that certain 4-substituted 2-hydroxylaminomethyl phenols or their nontoxic pharmaceutically acceptable acid addition salts are excellent diuretic, saluretic and anti-inflammatory agents.
THE USE OF STERICALLY HINDERED BENZYLAMINES IN THE SOMMELET REACTION
Stokker, G. E.,Schultz, E. M.
, p. 847 - 854 (2007/10/02)
A number of 2- and 2,6-disubstituted benzylamines have been successfully converted to the corresponding benzaldehydes via the Sommelet reaction in yields of 17-68percent.
2-(Aminomethyl)phenols, a New Class of Saluretic Agents. 4. Effects of Oxygen and/or Nitrogen Substitution
Stokker, G. E.,Deana, A. A.,deSolms, S. J.,Schultz, E. M.,Smith, R. L.,et al.
, p. 735 - 742 (2007/10/02)
A series of oxygen and/or nitrogen substituted 2-(aminomethyl)phenols was synthesized and tested orally in rats for saluretic and diuretic effects.Intravenous dog data are included as supplementary material to demonstrate diuretic responses, or lack thereof, in a secon species.In general, substitution on nitrogen with groups other than lower alkyl or substitution on nitrogen and/or oxygen with groups resistant to hydrolysis substantially diminished or ablated saluretic effects.
Derivatives of 1,2-benzisoxazoles
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, (2008/06/13)
Substituted 1,2-benzisoxazoles of the formula STR1 where: R1 and R3 =H or lower alkoxy; R2 =halo or α-branched lower alkyl; R4 =halo, halo lower alkyl, or lower alkylthio; provided, where R1 and Rsup
Nuclear substituted 2-hydroxyphenylmethanesulfamic acids
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, (2008/06/13)
Nuclear substituted 2-hydroxyphenylmethanesulfamic acids and their pharmaceutically acceptable salts wherein the phenyl nucleus is substituted with 2 to 4 nuclear substituents and which are useful saluretic-diuretics and anti-inflammatories are disclosed.
