71064-03-4Relevant academic research and scientific papers
A Novel Synthesis of 2-Ferrocenoyl-Substituted Iodobenzofurans
Li, Yang,Zhuoma, Bairenqing,Gao, Wentao
, p. 764 - 768 (2017)
In the present investigation, the first construction of a series of structurally new 2-ferrocenoyl-substituted iodobenzofurans hybrids has been achieved through a simple and mild two-step procedure, involving the iodination of salicylaldehydes using N-iodosuccinimide reagent in eco-friendly PEG-400 medium at room temperature followed by one-pot Rap–Stoermer reaction with 1-chloroacetylferrocene in refluxing MeCN with the presence of K2CO3as base and PEG-400 as the activated additive. These newly synthesized compounds belong to a new class of ferrocene-benzofuran hybrids and could be good candidates for the development of compounds for use in medicinal chemistry.
THE USE OF STERICALLY HINDERED BENZYLAMINES IN THE SOMMELET REACTION
Stokker, G. E.,Schultz, E. M.
, p. 847 - 854 (2007/10/02)
A number of 2- and 2,6-disubstituted benzylamines have been successfully converted to the corresponding benzaldehydes via the Sommelet reaction in yields of 17-68percent.
2-(Aminomethyl)phenols, a New Class of Saluretic Agents. 4. Effects of Oxygen and/or Nitrogen Substitution
Stokker, G. E.,Deana, A. A.,deSolms, S. J.,Schultz, E. M.,Smith, R. L.,et al.
, p. 735 - 742 (2007/10/02)
A series of oxygen and/or nitrogen substituted 2-(aminomethyl)phenols was synthesized and tested orally in rats for saluretic and diuretic effects.Intravenous dog data are included as supplementary material to demonstrate diuretic responses, or lack thereof, in a secon species.In general, substitution on nitrogen with groups other than lower alkyl or substitution on nitrogen and/or oxygen with groups resistant to hydrolysis substantially diminished or ablated saluretic effects.
2-Hydroxylaminomethyl phenols
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, (2008/06/13)
It has been found that certain 4-substituted 2-hydroxylaminomethyl phenols or their nontoxic pharmaceutically acceptable acid addition salts are excellent diuretic, saluretic and anti-inflammatory agents.
Derivatives of 1,2-benzisoxazoles
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, (2008/06/13)
Substituted 1,2-benzisoxazoles of the formula STR1 where: R1 and R3 =H or lower alkoxy; R2 =halo or α-branched lower alkyl; R4 =halo, halo lower alkyl, or lower alkylthio; provided, where R1 and Rsup
Nuclear substituted 2-hydroxyphenylmethanesulfamic acids
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, (2008/06/13)
Nuclear substituted 2-hydroxyphenylmethanesulfamic acids and their pharmaceutically acceptable salts wherein the phenyl nucleus is substituted with 2 to 4 nuclear substituents and which are useful saluretic-diuretics and anti-inflammatories are disclosed.
