38957-45-8

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 296275-13-3 methyl 2-(4-nitrophenylsulfonamido)benzoate 
• 330468-48-9 2-(4-nitro-benzenesulfonylamino)benzoic acid ethyl ester 
• 118-92-3 anthranilic acid 

Downstream Products

• 1446489-53-7 N-(3,4-dichlorophenyl)-2-(4-nitrophenylsulfonamido)benzamide 
• 1446489-50-4 N-(3-chloro-4-fluorophenyl)-2-(4-nitrophenylsulfonamido)benzamide 
• 1446489-51-5 N-(3-(difluoromethoxy)phenyl)-2-(4-nitrophenylsulfonamido)benzamide 
• 1446489-52-6 2-(4-nitrophenylsulfonamido)-N-(3-(trifluoromethoxy)phenyl)benzamide 
• 1446489-48-0 N-(2,4-dichlorophenyl)-2-(4-nitrophenylsulfonamido)benzamide 
• 1454274-90-8 N-(4-methyl-3-(trifluoromethyl)phenyl)-2-(4-nitrophenylsulfonamido)benzamide 
• 1608117-84-5 N-benzyl-N-(4-methylpenta-2,3-dienyl)-2-(4-nitrophenylsulfonamido)benzamide 

Relevant academic research and scientific papers

Synthesis, crystal structure and studies on the interaction with albumin of a new silver(I) complex base on 2-(4-nitrobenzenesulfonamido)benzoic acid

In the present work, the two-dimensional (2D) polymer poly[[μ4-2-(4-nitrobenzenesulfonamido)benzoato-κ4 O 1:O 1:O 1′:N 6]silver(I)] (AgL), [Ag(C13H9N2O6S)] n , was obtained from 2-(4-nitrobenzenesulfonamido)benzoic acid (HL), C13H10N2O6S. FT-IR, 1H and 13

Hydroxamic acid with benzenesulfonamide: An effective scaffold for the development of broad-spectrum metallo-β-lactamase inhibitors

Given that β-lactam antibiotic resistance mediated by metallo-β-lactamases (MβLs) seriously threatens human health, we designed and synthesized nineteen hydroxamic acids with benzenesulfonamide, which exhibited broad-spectrum inhibition against four teste

Synthesis, crystal structure and studies on the interaction with albumin of a new silver(I) complex based on 2-(4-nitrobenzenesulfonamido)benzoic acid

In the present work, the two-dimensional (2D) polymer poly[[μ 4-2-(4-nitrobenzenesulfonamido) benzoato-κ4O1:O1:ó :N6]silver(I)] (AgL), [Ag(C13H9- N2O6S)]n, was obtained from 2-(4-nitrobenzenesulfonamido)benzoic acid (HL), C13H10N2O6S. FT-IR, 1H and 13C{1H} NMR spectroscopic analyses were used to characterize both compounds. The crystal structures of HL and AgL were determined by single-crystal X-ray diffraction. In the structure of HL, O-HO hydrogen bonds between neighbouring molecules result in the formation of dimers, while the silver(I) complex shows polymerization associated with the O atoms of three distinct deprotonated ligands (L). Thus, the structure of the Ag complex can be considered as a coordination polymer consisting of a one-dimensional linear chain, constructed by carboxylate bridging groups, running parallel to the b axis. Neighbouring polymeric chains are further bridged by Ag-C monohapto contacts, resulting in a 2D framework. Fingerprint analysis of the Hirshfeld surfaces show that OH/HO hydrogen bonds are responsible for the most significant contacts in the crystal packing of HL and AgL, followed by the HH and OC/CO interactions. The AgAg, AgO/OAg and AgC/CAg interactions in the Hirshfeld surface represent 12.1% of the total interactions in the crystal packing. Studies of the interactions of the compounds with human serum albumin (HSA) indicated that both HL and AgL interact with HSA.

Arylsulfonylamino-benzanilides as inhibitors of the apical sodium-dependent bile salt transporter (SLC10A2)

The apical sodium-dependent bile salt transporter (ASBT) plays a pivotal role in maintaining bile acid homeostasis. Inhibition of ASBT would reduce bile acid pool size and lower cholesterol levels. In this report, a series of novel arylsulfonylaminobenzan

Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction

We report the molecular design and synthesis of EG00229,2, the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRPl) and the structural characterization of NRPl-ligand complexes by NMR spectroscopy and X-ray crystallography. Mutagenesis studies localized VEGF-A binding in the NRPl bl domain and a peptide fragment of VEGF-A was shown to bind at the same site by NMR, providing the basis for small molecule design. Compound 2 demonstrated inhibition of VEGF-A binding to NRPl and attenuated VEGFR2 phosphorylation in endothelial cells. Inhibition of migration of endothelial cells was also observed. The viability of A549 lung carcinoma cells was reduced by 2, and it increased the potency of the cytotoxic agents paclitaxel and 5-fluorouracil when given in combination. These studies provide the basis for design of specific small molecule inhibitors of ligand binding to NRP1.

Kinetics of arylsulfonation of aminobenzoic acids with m-and p-nitrobenzenesulfonyl chlorides in the system water-2-propanol

The concentrations of the uncharged and anionic forms of m-and p-aminobenzoic acids participating in arylsulfonation of the acids with m-and p-nitrobenzenesulfonyl chlorides in the system water-2-propanol at 298 K at various water contents and pHs were estimated. The resulting data were used to estimate the rate constants for the reactions of the above forms with nitrobenzenesulfonyl chlorides, based on experimental kinetic data.