389634-86-0

Basic information

• Product Name: 2-(4-tert-butoxycarbonylamino-2-{butyl-[(3-hydroxy-phenyl)-acetyl]-amino}-butyrylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester
• Synonyms: 2-(4-tert-butoxycarbonylamino-2-{butyl-[(3-hydroxy-phenyl)-acetyl]-amino}-butyrylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester
• CAS NO: 389634-86-0
• Molecular Weight: 632.686
• Mol File: 389634-86-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-tert-butoxycarbonylamino-2-{butyl-[(3-hydroxy-phenyl)-acetyl]-amino}-butyrylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-tert-butoxycarbonylamino-2-{butyl-[(3-hydroxy-phenyl)-acetyl]-amino}-butyrylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester(389634-86-0)
• EPA Substance Registry System: 2-(4-tert-butoxycarbonylamino-2-{butyl-[(3-hydroxy-phenyl)-acetyl]-amino}-butyrylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester(389634-86-0)

Safety Data

• Hazardous Substances Data: 389634-86-0(Hazardous Substances Data)

Upstream product

• 58885-60-2 N-(tert-butoxycarbonyl)-3-aminopropanal 
• 621-37-4 m-hydroxyphenylacetic acid 
• 109-73-9 N-butylamine 
• 389635-00-1 3-(4-fluoro-3-nitrophenyl)-2-isocyanopropionic acid methyl ester 

Relevant articles and documents

Rapid and diverse route to natural product-like biaryl ether containing macrocycles

A two-step sequence involving an Ugi four-component reaction and an intramolecular nucleophilic aromatic substitution (SNAr) has been developed for the rapid access to biaryl-ether containing macrocycles. In the course of this study, we documented that ammonium chloride can promote the Ugi-4CR in non-polar aprotic solvent (toluene) without the interference of an alternative Passerini reaction. Solid phase synthesis of macrocycles by this two-step sequence was also developed using polymer (Wang resin) supported α-(4′-fluoro-3′-nitro)phenethyl isocyanoacetate as one of the inputs.