389635-22-7

Upstream product

• 25026-34-0 4-chlorophenacetyl chloride 
• 296281-97-5 N-(N-anthranoyl) anthranoyl-DL-phenylalanine ethyl ester 
• 610-14-0 2-nitrobenzyl chloride 
• 32771-73-6 2(R,S)-(2-amino-benzoylamino)-3-phenyl-propionic acid ethyl ester 
• 1795-96-6 phenylalanine ethyl ester 
• 118-48-9 isatoic anhydride 

Relevant academic research and scientific papers

Synthesis of N-terminal substituted anthranilic acid dimer derivatives for evaluation on CCK receptors

A series of new N-substituted anthranilic acid dimer derivatives having a C-terminal Phe residue was synthesized and evaluated for their affinity for CCK receptors. These compounds resulted from a blended approach based firstly on the use of an alternative substructure embedded within asperlicin and secondly on the derivatization of this template with substituents chosen considering the C-terminal primary structure of the endogenous ligand. Although these compounds exhibited a regnylogical-type organization similar to that of CCK-4, they are characterized by about 1000-fold greater affinity for CCK-A receptor than the C-terminal tetrapeptide.