38982-27-3

Upstream product

• 6305-40-4 1,3-diiodopropan-2-one 
• 96-26-4 dihydroxyacetone 
• 98-88-4 benzoyl chloride 
• 582-25-2 Potassium benzoate 
• 534-07-6 1,3-Dichloroacetone 
• 111163-30-5 2,2-diethoxy-1,3-bis-benzoyloxy-propane 

Downstream Products

• 40593-13-3 benzoic acid 3-hexanoyloxy-2-hydroxypropyl ester 

Relevant academic research and scientific papers

COMPOUNDS FOR TREATING OR INHIBITING RECURRENCE OF ACUTE MYELOID LEUKEMIA

Provided herein are compounds for treating acute myeloid leukemia or inhibiting recurrence of acute myeloid leukemia and for inhibiting growth of and/or killing leukemic stem cells.

Efficient oxidation of 1,2-diols into a-hydroxyketones catalyzed by organotin compounds

Electrochemical oxidation of 1,2-diols with a catalytic amount of an organotin compound and a bromide ion as mediators has been developed. Various cyclic and acyclic 1,2-diols were oxidized into the corresponding α-hydroxyketones in good to excellent yields without C-C bond cleavage. Also, oxidation with the use of chemical oxidants was accomplished in the presence of a catalytic amount of an organotin compound. These reactions could discriminate 1,2-diols from isolated hydoxyl groups or 1,3-diols. In the case of a conformationally restricted cyclic 1,2-diol, the axial hydroxyl group was oxidized exclusively. Mono-, di-, and trialkylated tin compounds were examined as mediators and dialkylated tin compounds showed higher catalytic activity than mono- and trisubstituted ones. Me2SnCl2 was found to be the most suitable mediator for the selective oxidation..

Catalytic Ability of Flexible Octopus-Type Calixarene in Ester-Forming Reactions and Its Structural Properties

The ester-forming reaction of alkali metal carboxylates with alkyl halides was catalyzed by the octopus-type calixarene 1 which bears six 3,6,9-trioxadecyl substituents at the phenolic oxygens.The catalytic ability of 1 was significantly large in CH2Cl2 and CH3CN but negligible in less polar solvents such as benzene and dioxane.The catalytic ability is also affected by the amount of water present in the reaction system.A similar solvent effect was found in the alkali metal cation extraction by 1 from aqueous solutions to organic solvents.The conformation and structural mobility of 1 in organic solvents were studied by (1)H NMR spectroscopy at varying temperatures.Compound 1 had a 1,4-anti conformation (see Figure 4) both in CD2Cl2 and C6D6, but the orientation of the substituents on the aromatic rings of 1 varied with temperature.The reactivity features of 1 are discussed on the basis of its structural properties.

Enatioselective Microbial Reduction of Monoesters of 1,3-Dihydroxypropanone: Synthesis of (S)- and (R)-1,2-O-Isopropylideneglycerol

The reduction of 3-benzoyloxy-1-hydroxypropanone with bakers' yeast proceeds enantioselectively to afford (S)-3-benzoyloxy-1,2-propanediol, which may be further converted into (S)-(benzoyloxymethyl)oxirane.The bioreduction with fermenting yeast of 1-acetoxy-3-benzyloxypropanones gives (R)-1-benzyloxy-3-acetoxy-2-propanol which can be used for the preparation of both (S)- and (R)-1,2-O-isopropylideneglycerol.